The effects of perceived stress and anhedonic depression on mnemonic similarity task performance.
The effects of perceived stress and anhedonic depression on mnemonic similarity task performance.
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DOI：
10.1016/j.nlm.2022.107648
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发表时间：
2022-09
影响因子：
2.7
通讯作者：
Davidson, Richard J.
中科院分区：
文献类型：
--
作者：
Grupe, Daniel W.;Fitch, Dan;Vack, Nathan J.;Davidson, Richard J.
先前的研究已经证明，经历高压力的个体的海马体会发生变化。助记相似性任务（MST）是一项海马依赖性任务，对与年龄相关的海马衰退敏感，但尚不清楚该任务的表现与一个人的日常压力经历有何关系。我们对 510 名完成了四项不同 Mechanical Turk 研究中 MST 的参与者进行了单独的发现和复制分析。我们假设，感知压力量表的得分越高，与之前看到的目标（模式分离的行为指数）中的“诱惑”项目的辨别能力越差有关，但与识别记忆无关。在发现或复制样本中，感知压力和诱饵辨别之间的零阶关系并不显着。涉及快感缺乏抑郁症症状（来自情绪和焦虑症状问卷）的探索性分析揭示了发现样本中强烈的感知压力*快感缺乏抑郁症相互作用，这在复制样本中得到了证实。在这两个样本中，快感缺失抑郁症状较低但不较高的个体表现出感知压力与诱饵辨别能力之间呈负相关。与假设相反，在识别记忆中观察到类似的相互作用。感知压力和行为模式分离之间的新关联表明，候选行为过程与压力相关的海马缺陷相关。这种效应对于快感缺乏抑郁症症状较低的个体的特异性以及行为特异性的缺乏突出表明需要进行额外的研究来揭示这些发现的临床和神经生物学意义。
Previous research has demonstrated hippocampal alterations in individuals experiencing elevated stress. The Mnemonic Similarity Task (MST) is a hippocampal-dependent task sensitive to age-related hippocampal decline, but it is unknown how performance on this task is related to one’s experience of daily stress. We conducted separate discovery and replication analyses in 510 participants who completed the MST across four different Mechanical Turk studies. We hypothesized that higher scores on the Perceived Stress Scale would be associated with poorer discrimination of “lure” items from previously seen targets – a behavioral index of pattern separation – but not with recognition memory. The zero-order relationship between perceived stress and lure discrimination was not significant in the discovery or replication sample. Exploratory analyses involving anhedonic depression symptoms (from the Mood and Anxiety Symptoms Questionnaire) revealed a robust perceived stress*anhedonic depression interaction in the discovery sample that was confirmed in the replication sample. In both samples, individuals with low but not high anhedonic depression symptoms showed an inverse association between perceived stress and lure discrimination ability. Contrary to hypotheses, a similar interaction was observed for recognition memory. The novel association between perceived stress and behavioral pattern separation suggests a candidate behavioral process associated with stress-related hippocampal deficits. The specificity of this effect for individuals with low anhedonic depression symptoms – and the lack of behavioral specificity – highlight the need for additional research to unpack the clinical and neurobiological significance of these findings.
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