Case-control genome-wide association study of attention-deficit/hyperactivity disorder.
Case-control genome-wide association study of attention-deficit/hyperactivity disorder.
复制标题
DOI：
10.1016/j.jaac.2010.06.007
复制
发表时间：
2010-09
影响因子：
13.3
通讯作者：
IMAGE II Consortium Group
中科院分区：
文献类型：
--
作者：
Neale BM;Medland S;Ripke S;Anney RJ;Asherson P;Buitelaar J;Franke B;Gill M;Kent L;Holmans P;Middleton F;Thapar A;Lesch KP;Faraone SV;Daly M;Nguyen TT;Schäfer H;Steinhausen HC;Reif A;Renner TJ;Romanos M;Romanos J;Warnke A;Walitza S;Freitag C;Meyer J;Palmason H;Rothenberger A;Hawi Z;Sergeant J;Roeyers H;Mick E;Biederman J;IMAGE II Consortium Group
虽然双胞胎和家庭研究表明注意力缺陷/多动障碍（ADHD）是高度遗传的，但影响全基因组显著水平的遗传变异尚未确定。因此，需要额外的全基因组关联研究（GWAS）。我们使用病例对照分析，对896例DSM-IV ADHD病例进行了基因分型，使用了Affyoung 5.0阵列，并对2，455名储存库对照进行了精神病和双相症状基因分型，使用了Affyoung 6.0阵列。使用BEAGLE 3.0对共有SNP集进行插补，得到1，033，244个SNP的分析数据集。使用广义线性模型分析数据。最显著的结果涉及以下基因：PRKG 1、FLNC、TCERG 1 L、PPM 1H、NXPH 1、PPM 1H、CDH 13、HK 1和HKDC 1。目前的分析是对现有文献的有益补充，并将对未来的荟萃分析做出有价值的贡献。候选基因的发现与先前的荟萃分析一致，表明ADHD风险变体的影响必须单独非常小和/或包括多个罕见等位基因。
Although twin and family studies have shown attention deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus, additional genomewide association studies (GWAS) are needed. We used case-control analyses of 896 cases with DSM-IV ADHD genotyped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. The data were analyzed using a generalized linear model. No genome-wide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1 and HKDC1. The current analyses are a useful addition to the present literature and will make a valuable contribution to future meta-analyses. The candidate gene findings are consistent with a prior meta-analysis in suggesting that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles.
登录
查看更多内容
影响因子：
11
作者：
Asherson, P.;Zhou, K.;Faraone, S. V.
通讯作者：
Faraone, S. V.
影响因子：
11
作者：
Brookes, K.;Xu, X.;Johansson, L.
通讯作者：
Johansson, L.
影响因子：
3
作者：
Faraone, Stephen V;Biederman, Joseph
通讯作者：
Biederman, Joseph
影响因子：
4.2
作者：
Faraone, Stephen V.;Adamson, Joel J.;Biederman, Joseph
通讯作者：
Biederman, Joseph
影响因子：
30.8
作者：
Ferreira, Manuel A. R.;O'Donovan, Michael C.;Meng, Yan A.;Jones, Ian R.;Ruderfer, Douglas M.;Jones, Lisa;Fan, Jinbo;Kirov, George;Perlis, Roy H.;Green, Elaine K.;Smoller, Jordan W.;Grozeva, Detelina;Stone, Jennifer;Nikolov, Ivan;Chambert, Kimberly;Hamshere, Marian L.;Nimgaonkar, Vishwajit L.;Moskvina, Valentina;Thase, Michael E.;Caesar, Sian;Sachs, Gary S.;Franklin, Jennifer;Gordon-Smith, Katherine;Ardlie, Kristin G.;Gabriel, Stacey B.;Fraser, Christine;Blumenstiel, Brendan;Defelice, Matthew;Breen, Gerome;Gill, Michael;Morris, Derek W.;Elkin, Amanda;Muir, Walter J.;McGhee, Kevin A.;Williamson, Richard;MacIntyre, Donald J.;MacLean, Alan W.;Clair, David St;Robinson, Michelle;Van Beck, Margaret;Pereira, Ana C. P.;Kandaswamy, Radhika;McQuillin, Andrew;Collier, David A.;Bass, Nicholas J.;Young, Allan H.;Lawrence, Jacob;Ferrier, I. Nicol;Anjorin, Adebayo;Farmer, Anne;Curtis, David;Scolnick, Edward M.;McGuffin, Peter;Daly, Mark J.;Corvin, Aiden P.;Holmans, Peter A.;Blackwood, Douglas H.;Gurling, Hugh M.;Owen, Michael J.;Purcell, Shaun M.;Sklar, Pamela;Craddock, Nick
通讯作者：
Craddock, Nick