Neutrophil/lymphocyte ratio is correlated with levels of inflammatory markers and is significantly reduced by smoking cessation.
Neutrophil/lymphocyte ratio is correlated with levels of inflammatory markers and is significantly reduced by smoking cessation.
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DOI：
10.1177/03000605211019223
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Hasegawa K
中科院分区：
文献类型：
--
作者：
Komiyama M;Ozaki Y;Miyazaki Y;Katanasaka Y;Sunagawa Y;Funamoto M;Shimizu K;Yamakage H;Sato-Asahara N;Yasoda A;Wada H;Morimoto T;Hasegawa K
既往研究表明，中性粒细胞与淋巴细胞比值（NLR）与心血管疾病（CVD）的发生和预后有关。吸烟是心血管疾病的主要危险因素，戒烟可显著降低心血管疾病的风险。然而，戒烟对NLR的影响仍然未知。在访问我们戒烟诊所的吸烟者中，我们检查了戒烟前后NLR和CVD生物标志物的变化。共有389名个体（301名男性和88名女性）入组研究。成功戒烟后，中位NLR显著降低（戒烟前：1.8，四分位距[IQR] 1.5，2.5;戒烟后：1.7，IQR 1.3，2.4）。在根据性别调整的线性回归模型中，戒烟前后NLR的百分比变化与C反应蛋白（β = 0.260）、α1-抗胰蛋白酶-低密度脂蛋白（β = 0.151，p < 0.05）和血清淀粉样蛋白A-低密度脂蛋白（β = 0.325）的百分比变化呈显着正相关。我们的研究首次证明，戒烟可显著降低NLR以及炎症和氧化应激标志物。
Previous studies have reported that the neutrophil to lymphocyte ratio (NLR) is associated with onset and prognosis of cardiovascular disease (CVD). Smoking is a major risk factor for CVD and smoking cessation significantly reduces CVD risk. However, the effects of smoking cessation on the NLR remain unknown. Among smokers visiting our smoking cessation clinics, we examined changes in the NLR and CVD biomarkers before and after smoking cessation. A total of 389 individuals (301 men and 88 women) were enrolled in the study. The median NLR was significantly reduced after successful smoking cessation (before: 1.8, interquartile range [IQR] 1.5, 2.5; after: 1.7, IQR 1.3, 2.4). In a linear regression model adjusted for sex, percent change in NLR comparing before and after smoking cessation was significantly and positively correlated with percent changes in C-reactive protein (β = 0.260), α1-antitrypsin-low density lipoprotein (β = 0.151, p < 0.05), and serum amyloid A-low density lipoprotein (β = 0.325). Our study demonstrated for the first time that smoking cessation significantly reduces the NLR in tandem with markers of inflammation and oxidative stress.
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DOI：
10.1177/0300060517749130
发表时间：
2018-03
期刊：
The Journal of international medical research
影响因子：
--
作者：
Derya MA;Demir V;Ede H
通讯作者：
Ede H
影响因子：
12.3
作者：
Karaman, Murat;Balta, Sevket;Bozoglu, Ergun
通讯作者：
Bozoglu, Ergun
影响因子：
2.5
作者：
Ayhan, Huseyin;Kasapkara, Haci Ahmet;Bozkurt, Engin
通讯作者：
Bozkurt, Engin
影响因子：
1.5
作者：
Komiyama M;Wada H;Ura S;Yamakage H;Satoh-Asahara N;Shimada S;Akao M;Koyama H;Kono K;Shimatsu A;Takahashi Y;Hasegawa K
通讯作者：
Hasegawa K
DOI：
10.1056/nejmoa1803626
发表时间：
2018-08-16
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hu Y;Zong G;Liu G;Wang M;Rosner B;Pan A;Willett WC;Manson JE;Hu FB;Sun Q
通讯作者：
Sun Q