Positively increased visceral adiposity index in hyperuricemia free of metabolic syndrome.
Positively increased visceral adiposity index in hyperuricemia free of metabolic syndrome.
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DOI：
10.1186/s12944-018-0761-1
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发表时间：
2018-05-07
影响因子：
4.5
通讯作者：
Qu Q
中科院分区：
文献类型：
--
作者：
Gu D;Ding Y;Zhao Y;Miao S;Qu Q
内脏脂肪指数（VAI）与代谢综合征密切相关，但几乎没有研究关注VAI与高尿酸血症的关系，因此，本研究旨在确定VAI与无代谢综合征的高尿酸血症的关系，并评估VAI作为高尿酸血症预测因子的能力。一项来自健康检查项目的横断面研究进行了。所有参与者根据VAI四分位数分为四组。采用多变量logistic分析分析四分位数与高尿酸血症之间的关系。采用受试者工作特征（ROC）曲线分析评价预测高尿酸血症的准确性。VAI是高尿酸血症的独立危险因素。模型1中，经年龄、收缩压、舒张压、心率、空腹血糖、血清肌酐、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇校正后，上四分位数的ORs为3.077 (95%CI 1.78 ~ 5.293), P = 0.000；和3.041 (95CI 1.767-5.233), P = 0.000，在模型2中，校正上述因素后，加上体力活动、饮食、吸烟习惯、饮酒、高血压和糖尿病史。VAI的ROC曲线下面积（AUC）值为0.618 (95%CI 0.572 ~ 0.665), P = 0.000；高尿酸血症的血药浓度高于WC，为0.556 (95%CI 0.508 ~ 0.604), P = 0.024。在无代谢综合征的个体中，VAI与高尿酸血症相关，也是一个强有力的指标。
Visceral adiposity index (VAI) was closely associated with metabolic syndrome, however almost no research focused on VAI and hyperuricemia, therefore, this study was conducted to determine the relationship of VAI and hyperuricemia free of metabolic syndrome and estimate the power of VAI as predictor for hyperuricemia. A cross-sectional research coming from a health check-up program was conducted. All participants were divided into four groups according to VAI quartiles. A multivariate logistic analysis was used to analyze the relationship between the quartiles and hyperuricemia. A receiver operating characteristic (ROC) curve analysis was used to evaluate the accuracy of predictions for hyperuricemia. VAI was independent risk factor of hyperuricemia. The ORs of which in the upper quartile were 3.077 (95%CI 1.78-5.293), P = 0.000, in model 1, after adjusting for age, systolic blood pressure, diastolic blood pressure, heart rate, fast plasma glucose, serum creatinine, triglyceride, total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol; and 3.041 (95CI 1.767-5.233), P = 0.000, in model 2, after adjusting for the above plus physical activity, diet, smoking habits, alcohol consumption, hypertension and diabetes history. The area under the ROC curve (AUC) value of VAI was 0.618 (95%CI 0.572-0.665), P = 0.000; it was higher than WC, which was 0.556 (95%CI 0.508-0.604), P = 0.024, for hyperuricemia. VAI was associated with hyperuricemia among individuals free of metabolic syndrome, and also a powerful indicator.
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影响因子：
5.2
作者：
Das UN
通讯作者：
Das UN
影响因子：
4.5
作者：
Chen C;Xu Y;Guo ZR;Yang J;Wu M;Hu XS
通讯作者：
Hu XS
影响因子：
3.7
作者：
Ding Y;Gu D;Zhang Y;Han W;Liu H;Qu Q
通讯作者：
Qu Q
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
5.9
作者：
Gariballa S;Kosanovic M;Yasin J;El Essa A
通讯作者：
El Essa A