Genomic Analysis Reveals Human-Mediated Introgression From European Commercial Pigs to Henan Indigenous Pigs.
Genomic Analysis Reveals Human-Mediated Introgression From European Commercial Pigs to Henan Indigenous Pigs.
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DOI：
10.3389/fgene.2021.705803
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发表时间：
2021
影响因子：
3.7
通讯作者：
Han X
中科院分区：
文献类型：
--
作者：
Wang K;Zhang L;Duan D;Qiao R;Li X;Li X;Han X
据报道，欧洲猪的遗传特征渗入中国猪可能有助于提高生产力性状，如饲料转化效率和体型。然而，与欧洲猪的基因组差异以及基因渗入在河南土猪中的潜在作用仍不清楚。在本研究中，我们发现欧洲猪基因组显著渗入中国地方猪，特别是河南地方猪。河南地方猪尤其是南阳黑猪的基因渐渗主要来自杜洛克猪。最重要的是，我们发现NR 6A 1、GPD 2和CSRNP 3基因通过人工选择进行了基因渗入和重塑，这些可能有助于猪体尺和饲料转化效率的增加。我们的研究结果表明，人类介导的渐渗和选择重塑了河南猪的基因组，并改善了它们的几个期望的性状。这些研究结果有助于我们了解河南地方猪的历史，并为深入了解影响猪种群经济重要性状的遗传机制提供了依据。
Introgression of genetic features from European pigs into Chinese pigs was reported possibly contributing to improvements in productivity traits, such as feed conversion efficiency and body size. However, the genomic differences from European pigs and the potential role of introgression in Henan indigenous pigs remains unclear. In this study, we found significant introgression from European pigs into the genome of Chinese indigenous pigs, especially in Henan indigenous pigs. The introgression in Henan indigenous pigs, particularly in the Nanyang black pig, was mainly derived from Duroc pigs. Most importantly, we found that the NR6A1, GPD2, and CSRNP3 genes were introgressed and reshaped by artificial selection, and these may have contributed to increases in pig body size and feed conversion efficiency. Our results suggest that human-mediated introgression and selection have reshaped the genome of Henan pigs and improved several of their desired traits. These findings contribute to our understanding of the history of Henan indigenous pigs and provide insights into the genetic mechanisms affecting economically important traits in pig populations.
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