Genomic analysis reveals selection for Asian genes in European pigs following human-mediated introgression.
Genomic analysis reveals selection for Asian genes in European pigs following human-mediated introgression.
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DOI：
10.1038/ncomms5392
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发表时间：
2014-07-15
影响因子：
16.6
通讯作者：
Groenen, Martien A. M.
中科院分区：
文献类型：
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作者：
Bosse, Mirte;Megens, Hendrik-Jan;Frantz, Laurent A. F.;Madsen, Ole;Larson, Greger;Paudel, Yogesh;Duijvesteijn, Naomi;Harlizius, Barbara;Hagemeijer, Yanick;Crooijmans, Richard P. M. A.;Groenen, Martien A. M.
大约10，000年前，亚洲和欧洲当地野猪种群的独立驯化导致了不同的欧洲和亚洲猪品种，每种猪都有非常不同的表型特征。在工业革命期间，中国品种被进口到欧洲，以改善欧洲品种的商业特性。在这里，我们证明了欧洲家猪中存在渗入的亚洲单倍型，并使用全基因组序列数据在这些地区的一些位点上显示了选择特征。渐渗特征是广泛的，亚洲单倍型很少固定。亚洲渐渗的单倍型与包含涉及肉质、发育和生育力的基因的区域相关。我们确定了亚洲来源的AHR基因的非同义突变，这些突变与多个欧洲商业品系的窝仔数增加有关。这些发现表明，提高生育力是世纪早期养猪户的一个重要育种目标，并且在现代欧洲猪种的发展过程中，与该性状相关的亚洲基因变体被优先选择。 野猪种群的驯化导致了表型不同的欧洲和亚洲猪品种。在这里，作者表明，已经渗入欧洲猪种的亚洲单倍型含有控制经济上重要的性状，如肉质，发育和生育力的基因。
The independent domestication of local wild boar populations in Asia and Europe about 10,000 years ago led to distinct European and Asian pig breeds, each with very different phenotypic characteristics. During the Industrial Revolution, Chinese breeds were imported to Europe to improve commercial traits in European breeds. Here we demonstrate the presence of introgressed Asian haplotypes in European domestic pigs and selection signatures on some loci in these regions, using whole genome sequence data. The introgression signatures are widespread and the Asian haplotypes are rarely fixed. The Asian introgressed haplotypes are associated with regions harbouring genes involved in meat quality, development and fertility. We identify Asian-derived non-synonymous mutations in the AHR gene that associate with increased litter size in multiple European commercial lines. These findings demonstrate that increased fertility was an important breeding goal for early nineteenth century pig farmers, and that Asian variants of genes related to this trait were preferentially selected during the development of modern European pig breeds. Domestication of wild boar populations has led to phenotypically distinct European and Asian pig breeds. Here, the authors show that Asian haplotypes that have introgressed into European pig breeds harbour genes that control economically important traits such as meat quality, development and fertility.
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影响因子：
9.8
作者：
Boyko AR;Quignon P;Li L;Schoenebeck JJ;Degenhardt JD;Lohmueller KE;Zhao K;Brisbin A;Parker HG;vonHoldt BM;Cargill M;Auton A;Reynolds A;Elkahloun AG;Castelhano M;Mosher DS;Sutter NB;Johnson GS;Novembre J;Hubisz MJ;Siepel A;Wayne RK;Bustamante CD;Ostrander EA
通讯作者：
Ostrander EA
黄色皮肤基因的鉴定显示了家鸡的杂种起源。
影响因子：
4.5
作者：
Eriksson, Jonas;Larson, Greger;Gunnarsson, Ulrika;Bed'hom, Bertrand;Tixier-Boichard, Michele;Stromstedt, Lina;Wright, Dominic;Jungerius, Annemieke;Vereijken, Addie;Randi, Ettore;Jensen, Per;Andersson, Leif
通讯作者：
Andersson, Leif
影响因子：
5.8
作者：
Hernandez-Ochoa, Isabel;Karman, Bethany N.;Flaws, Jodi A.
通讯作者：
Flaws, Jodi A.
影响因子：
4.5
作者：
Bosse M;Megens HJ;Madsen O;Paudel Y;Frantz LA;Schook LB;Crooijmans RP;Groenen MA
通讯作者：
Groenen MA
影响因子：
64.8
作者：
通讯作者：
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