The Chlamydomonas cell cycle.
The Chlamydomonas cell cycle.
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DOI：
10.1111/tpj.12795
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Umen JG
中科院分区：
文献类型：
--
作者：
Cross FR;Umen JG
衣藻在真核生物系统发育中的地位使其至少在两个重要方面成为一种独特的模式：作为通往植物的至关重要的早期分歧谱系的代表；作为一种微生物，保留了在高度研究的酵母谱系中丢失的最后一个真核共同祖先(LECA)的重要特征。它的细胞生物学已经研究了几十年，它拥有成熟的实验遗传工具，包括经典的(孟德尔式)和分子的。与陆地植物不同，它是一种单倍体，基因重复很少，这使它成为功能丧失遗传学研究的理想选择。衣藻细胞周期在细胞生长和细胞快速分裂之间有着显著的时间和功能分离，可能与驱动光合作用的细胞生长和细胞分裂周期的昼夜周期之间的相互作用有关；它还表现出细胞周期和中心粒-基体-鞭毛周期之间高度编排的相互作用。在这里，我们对衣藻细胞周期的研究现状进行综述。我们首先概述了酵母和动物系统中的细胞周期控制，这已经产生了一个典型的、得到很好支持的模型。与这个模型相比，我们简要地讨论了植物细胞周期控制的相似性和差异性。接下来，我们对衣藻多分裂细胞周期的细胞学和细胞生物学进行综述。最后，我们回顾了最近的遗传方法和对衣藻细胞周期调控的见解，这些方法和见解已经被新一代基于基因组学的工具所启用。衣藻是包括细胞周期在内的许多真核生物学领域的优秀模型。它在绿色谱系中的系统发育地位和作为微生物遗传系统的用途赋予了这种生物巨大的潜力来解决关于真核细胞周期控制的悬而未决的问题，并定义管理细胞周期进程的新的调控机制。
The position of Chlamydomonas within the eukaryotic phylogeny makes it a unique model in at least two important ways: as a representative of the critically important, early‐diverging lineage leading to plants; and as a microbe retaining important features of the last eukaryotic common ancestor (LECA) that has been lost in the highly studied yeast lineages. Its cell biology has been studied for many decades and it has well‐developed experimental genetic tools, both classical (Mendelian) and molecular. Unlike land plants, it is a haploid with very few gene duplicates, making it ideal for loss‐of‐function genetic studies. The Chlamydomonas cell cycle has a striking temporal and functional separation between cell growth and rapid cell division, probably connected to the interplay between diurnal cycles that drive photosynthetic cell growth and the cell division cycle; it also exhibits a highly choreographed interaction between the cell cycle and its centriole–basal body–flagellar cycle. Here, we review the current status of studies of the Chlamydomonas cell cycle. We begin with an overview of cell‐cycle control in the well‐studied yeast and animal systems, which has yielded a canonical, well‐supported model. We discuss briefly what is known about similarities and differences in plant cell‐cycle control, compared with this model. We next review the cytology and cell biology of the multiple‐fission cell cycle of Chlamydomonas. Lastly, we review recent genetic approaches and insights into Chlamydomonas cell‐cycle regulation that have been enabled by a new generation of genomics‐based tools. Chlamydomonas is an excellent model for many areas of eukaryotic biology, including the cell cycle. Its phylogenetic position in the green lineage and its utility as a microbial genetic system give this organism great potential for addressing unanswered questions about eukaryotic cell cycle control and for defining new regulatory mechanisms that govern cell cycle progression.
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影响因子：
7.8
作者：
ADAMS, GMW;WRIGHT, RL;JARVIK, JW
通讯作者：
JARVIK, JW
影响因子：
3.3
作者：
Bernstein, Kara A.;Bleichert, Franziska;Baserga, Susan J.
通讯作者：
Baserga, Susan J.
影响因子：
3.3
作者：
ARMBRUST, EV;IBRAHIM, A;GOODENOUGH, UW
通讯作者：
GOODENOUGH, UW
影响因子：
64.8
作者：
DONNAN, L;JOHN, PCL
通讯作者：
JOHN, PCL
影响因子：
4
作者：
Dieckmann, CL
通讯作者：
Dieckmann, CL