Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men.
Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men.
复制标题
DOI：
10.1016/j.plefa.2013.04.001
复制
发表时间：
2013-07
影响因子：
3
通讯作者：
Schebb, Nils Helge
中科院分区：
文献类型：
--
作者：
Schuchardt, Jan Philipp;Schmidt, Simone;Kressel, Gaby;Dong, Hua;Willenberg, Ina;Hammock, Bruce D.;Hahn, Andreas;Schebb, Nils Helge
氧化脂质是不饱和脂肪酸（FA）的氧化产物，是一种内源性介质，参与炎症、疼痛和凝血等多种生物学过程的调节。与通过环氧合酶作用由花生四烯酸（AA）衍生的氧化脂质（即前列腺素）相比，关于人体内亚油酸（LA）、AA、α-亚麻酸（ALA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的羟基-、环氧-和二羟基-FA的内源性水平，仅有有限的信息可用。特别地，尚不清楚代谢紊乱如何影响人类的内源性氧脂素水平。因此，在本研究中，我们比较了20名正常血脂和20名高血脂（总胆固醇> 200 mg/dl; LDL-C > 130 mg/dl; TG > 150 mg/ml）男性（年龄29-51岁）的44种氧脂素的血清浓度。受试者之间的血清浓度差异很大。对于大多数羟基-，环氧-和二羟基-FA的浓度与早期研究中报告的血浆浓度相当。尽管血脂水平发生了显著变化，但高脂血症组的氧脂素水平只有微小差异。与血脂正常的受试者相比，高血脂受试者的8，9-DiHETrE、5-HEPE、10，11-DiHDPE的血清浓度略高，而12，13-DiHOME、12-HETE、9，10-DiHODE和12，13-DiHODE的浓度较低。总体而言，羟基，环氧和二羟基-FA水平没有变化，表明轻度混合型高脂血症对循环氧脂素的浓度没有明显影响。相比之下，血清中的几个羟基，环氧，和二羟基-FA的水平取决于父母FA的个人地位。特别地，观察到红细胞膜中的EPA含量与EPA衍生的氧脂素的血清浓度之间的强相关性。考虑到人体中其他n3-FA合成EPA的能力很低，这表明氧脂素水平可能直接受到饮食的影响。
Oxylipins, the oxidation products of unsaturated fatty acids (FA), are potent endogenous mediators being involved in regulation of various biological processes such as inflammation, pain and blood coagulation. Compared to oxylipins derived from arachidonic acid (AA) by cyclooxygenase action, i.e. prostanoides, only limited information is available about the endogenous levels of hydroxy-, epoxy- and dihydroxy-FA of linoleic acid (LA), AA, α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans. Particularly, it is unknown how metabolic disorders affect endogenous oxylipin levels in humans. Therefore, in the present study we compared the serum concentrations of 44 oxylipins in 20 normolipidemic with 20 hyperlipidemic (total cholesterol > 200 mg/dl; LDL-C > 130 mg/dl; TG > 150 mg/ml) men (age 29–51 y). The serum concentration varied strongly among subjects. For most hydroxy-, epoxy- and dihydroxy-FA the concentration were comparable to those of plasma reported in earlier studies. Despite the significant change in blood lipid levels the hyperlipidemic group showed only minor differences in oxylipin levels. The hyperlipidemic subjects had a slightly higher serum concentration of 8,9-DiHETrE, 5-HEPE, 10,11-DiHDPE, and a lower concentration of 12,13-DiHOME, 12-HETE, 9,10-DiHODE, and 12,13-DiHODE compared to normolipidemic subjects. Overall the hydroxy-, epoxy- and dihydroxy-FA levels were not changed suggesting that mild combined hyperlipidemia has no apparent effect on the concentration of circulating oxylipins. By contrast, serum levels of several hydroxy-, epoxy-, and dihydroxy-FA are dependent on the individual status of the parent FA. Particularly, a strong correlation between the EPA content in the erythrocyte membrane and the serum concentration of EPA derived oxylipins was observed. Given that the synthesis of EPA from other n3-FA in humans is low, this suggests that oxylipin levels can be directly influenced by the diet.
登录
查看更多内容
影响因子：
39.2
作者：
McLaughlin, T;Abbasi, F;Reaven, G
通讯作者：
Reaven, G
DOI：
10.1016/j.bbrc.2011.10.141
发表时间：
2011-12-09
影响因子：
3.1
作者：
Kogure, Ryouta;Toyama, Kazuya;Takeda, Shigeki
通讯作者：
Takeda, Shigeki
影响因子：
5.1
作者：
Harris, WS;von Schacky, C
通讯作者：
von Schacky, C
影响因子：
6.5
作者：
Keenan, Alison H.;Pedersen, Theresa L.;Newman, John W.
通讯作者：
Newman, John W.
DOI：
10.1016/j.plefa.2007.10.012
发表时间：
2007-11-01
影响因子：
3
作者：
Goodfriend, T. L.;Pedersen, T. L.;Vollmer, A.
通讯作者：
Vollmer, A.