Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases.
Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases.
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DOI：
10.1111/j.1468-3083.2012.04582.x
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Hata TR
中科院分区：
文献类型：
--
作者：
Afshar M;Martinez AD;Gallo RL;Hata TR
干扰素-α疗法用于治疗丙型肝炎感染。接受干扰素-α治疗的丙型肝炎患者银屑病的恶化和发生已被越来越多地认识到，但其明显的相关特征、病因和治疗尚未被综述。回顾所有已发表的丙型肝炎患者在接受干扰素-α治疗期间发生银屑病的病例。这项研究是通过在PubMed数据库中搜索关键词“丙型肝炎”和“牛皮癣”进行的。此外，还参考了未被PubMed编入索引的其他出版物，以获得已出版数据的完整记录。我们确定了32篇文章，描述了36名在接受丙型肝炎干扰素-α治疗时发生银屑病皮疹的受试者。局部疗法是一种常用的治疗方式，但只有30%的病例得到了解决。停止干扰素-α治疗后，93%的病例得到缓解。在接受干扰素-α治疗期间发生银屑病的人中，100%的人对系统治疗有反应，并能够继续服药。有必要对干扰素-α诱导的皮损进行进一步的研究和分析，以阐明干扰素-α和丙型肝炎病毒在银屑病皮损发展中的作用。
Interferon-alpha (IFN-α) therapy is used to treat hepatitis C infection. The exacerbation and occurrence of psoriasis in hepatitis C patients treated with IFN-α is increasingly recognized, but the distinct associated features, etiology, and management have not been reviewed. To review all published cases of hepatitis C patients who developed psoriasis while receiving IFN-α therapy. The review was conducted by searching the PubMed database using the keywords “hepatitis C” AND “psoriasis.” In addition, references to additional publications not indexed for PubMed were followed to obtain a complete record of published data. We identified 32 publications describing 36 subjects who developed a psoriatic eruption while receiving IFN-α therapy for hepatitis C. Topical therapies were a commonly employed treatment modality but led to resolution in only 30% of cases in which they were employed solely. Cessation of IFN-α therapy led to resolution in 93% of cases. 100% of those who developed psoriasis while on IFN-α therapy responded to systemic therapy and were able to continue the drug. Further studies and analysis of IFN-α-induced lesions are necessary to clarify the role of IFN-α and the hepatitis C virus in the development of psoriatic lesions.
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3.4
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