Pregnancy pesticide exposure and child development in low- and middle-income countries: A prospective analysis of a birth cohort in rural Bangladesh and meta-analysis.
Pregnancy pesticide exposure and child development in low- and middle-income countries: A prospective analysis of a birth cohort in rural Bangladesh and meta-analysis.
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DOI：
10.1371/journal.pone.0287089
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
尽管有大量证据表明高收入国家的孕妇接触农药与儿童发育之间存在负相关，但来自低收入和中等收入国家的证据有限。因此，我们评估了孟加拉国农村地区妊娠期农药暴露与儿童发育之间的关系，并在系统综述和荟萃分析中总结了现有文献。我们使用的数据来自2008年建立的出生队列中的284对母婴。在妊娠早期（平均胎龄11.6±2.9周）定量8种尿农药生物标志物作为农药暴露的指标。在20-40月龄时使用Bayley婴幼儿发育量表（第三版）。使用多变量广义线性模型估计肌酐校正的尿农药生物标志物浓度和儿童发育评分之间的关联。我们检索了截至2021年11月的10个数据库，以确定在中低收入国家进行的关于妊娠期农药暴露和儿童发育的前瞻性研究。我们使用随机效应模型来汇总类似的研究，包括我们的原始分析。该系统性综述已在PROSPERO中预注册：CRD 42021292919。在孟加拉国队列中，妊娠期2-异丙基-4-甲基-6-羟基嘧啶（IMPY）浓度与运动发育呈负相关（-0.66分[95% CI-1.23，-0.09]）。妊娠期3，5，6-三氯-2-吡啶酚（TCPY）浓度与认知发育呈负相关，但相关性很小：-0.02分（-0.04，0.01）。我们没有观察到4-硝基苯酚和3-苯氧基苯甲酸（3-PBA）浓度和儿童发育之间的关联。该系统评价包括来自4个LMIC的13项研究。在将我们的结果与另一项研究汇总后，我们发现一致的证据表明，妊娠期3-PBA浓度与认知，语言或运动发育无关。有证据表明，妊娠期接触某些有机磷农药与儿童发育呈负相关。在低收入国家采取干预措施，减少子宫内农药暴露，可能有助于保护儿童的发育。
Despite considerable evidence on a negative association between pregnancy pesticide exposure and child development in high-income countries, evidence from low- and middle-income countries (LMICs) is limited. Therefore, we assessed associations between pregnancy pesticide exposure and child development in rural Bangladesh and summarised existing literature in a systematic review and meta-analysis. We used data from 284 mother-child pairs participating in a birth cohort established in 2008. Eight urinary pesticide biomarkers were quantified in early pregnancy (mean gestational age 11.6±2.9 weeks) as an index of pesticide exposure. The Bayley Scales of Infant and Toddler Development, Third Edition were administered at 20–40 months of age. Associations between creatinine-adjusted urinary pesticide biomarker concentrations and child development scores were estimated using multivariable generalised linear models. We searched ten databases up to November 2021 to identify prospective studies on pregnancy pesticide exposure and child development conducted in LMICs. We used a random-effects model to pool similar studies, including our original analysis. The systematic review was pre-registered with PROSPERO: CRD42021292919. In the Bangladesh cohort, pregnancy 2-isopropyl-4-methyl-6-hydroxypyrimidine (IMPY) concentrations were inversely associated with motor development (-0.66 points [95% CI -1.23, -0.09]). Pregnancy 3,5,6-trichloro-2-pyridinol (TCPY) concentrations were inversely associated with cognitive development, but the association was small: -0.02 points (-0.04, 0.01). We observed no associations between 4-nitrophenol and 3-phenoxybenzoic acid (3-PBA) concentrations and child development. The systematic review included 13 studies from four LMICs. After pooling our results with one other study, we found consistent evidence that pregnancy 3-PBA concentrations were not associated with cognitive, language, or motor development. Evidence suggests that pregnancy exposure to some organophosphate pesticides is negatively associated with child development. Interventions to reduce in-utero pesticide exposure in LMICs may help protect child development.
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DOI：
10.1016/s0140-6736(16)31389-7
发表时间：
2017-01-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Black MM;Walker SP;Fernald LCH;Andersen CT;DiGirolamo AM;Lu C;McCoy DC;Fink G;Shawar YR;Shiffman J;Devercelli AE;Wodon QT;Vargas-Barón E;Grantham-McGregor S;Lancet Early Childhood Development Series Steering Committee
通讯作者：
Lancet Early Childhood Development Series Steering Committee
影响因子：
6
作者：
Donley, Nathan
通讯作者：
Donley, Nathan
影响因子：
11.8
作者：
Guo, Jianqiu;Wu, Chunhua;Zhou, Zhijun
通讯作者：
Zhou, Zhijun
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
11.8
作者：
Jaacks, Lindsay M.;Diao, Nancy;Christiani, David C.
通讯作者：
Christiani, David C.