Biologically active quinoline and quinazoline alkaloids part I.
Biologically active quinoline and quinazoline alkaloids part I.
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生物活性喹啉和喹唑啉生物碱第一部分
DOI：
10.1002/med.21466
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发表时间：
2018-05
影响因子：
13.3
通讯作者：
Lee KH
中科院分区：
文献类型：
--
作者：
Shang XF;Morris-Natschke SL;Liu YQ;Guo X;Xu XS;Goto M;Li JC;Yang GZ;Lee KH
喹啉和喹唑啉生物碱是两类重要的含氮杂环化合物，自19世纪世纪以来一直受到国内外研究者的广泛关注。在过去的200多年里，这两类化合物中有许多是从天然来源中分离出来的，其中大多数及其修饰类似物具有显著的生物活性。奎宁和喜树碱是两种最著名和最重要的喹啉类生物碱，它们的发现分别为抗疟和抗癌药物的开发开辟了新的领域。本文综述了2008年以前这两类生物活性生物碱的研究进展（第一部分）。综述了200多个具有广泛生物活性的分子，包括抗肿瘤、抗疟疾、抗细菌和抗真菌、抗寄生虫和杀虫、抗病毒、抗血小板、抗炎、除草、抗氧化等活性。这项调查应为从原始天然存在的喹啉和喹唑啉生物碱中发现新的更好的药物提供新的线索或可能性。
Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic compounds, have attracted tremendous attention from researchers worldwide since the 19th century. Over the past 200 years, many compounds from these two classes were isolated from natural sources, and most of them and their modified analogs possess significant bioactivities. Quinine and camptothecin are two of the most famous and important quinoline alkaloids, and their discoveries opened new areas in antimalarial and anticancer drug development, respectively. In this review, we survey the literature on bioactive alkaloids from these two classes and highlight research achievements prior to the year 2008 (Part I). Over 200 molecules with a broad range of bioactivities, including antitumor, antimalarial, antibacterial and antifungal, antiparasitic and insecticidal, antiviral, antiplatelet, anti-inflammatory, herbicidal, antioxidant and other activities, were reviewed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.
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影响因子：
3.7
作者：
Anand, Preetha;Kunnumakara, Ajaikumar B.;Sundaram, Chitra;Harikumar, Kuzhuvelil B.;Tharakan, Sheeja T.;Lai, Oiki S.;Sung, Bokyung;Aggarwal, Bharat B.
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Aggarwal, Bharat B.
影响因子：
3.3
作者：
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通讯作者：
Elipe, MVS
影响因子：
1.4
作者：
Ambrozin, Alessandra R. P.;Mafezoli, Jair;Albuquerque, Sérgio de
通讯作者：
Albuquerque, Sérgio de
影响因子：
5.1
作者：
BARROW, CJ;SUN, HH
通讯作者：
SUN, HH
影响因子：
1.6
作者：
Abe, M;Imai, T;Oki, T
通讯作者：
Oki, T