Plasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study.
Plasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study.
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DOI：
10.3390/nu14091697
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发表时间：
2022-04-19
期刊：
影响因子：
5.9
通讯作者：
Gill, Dipender
中科院分区：
文献类型：
--
作者：
Larsson, Susanna C.;Woolf, Benjamin;Gill, Dipender
我们在两个样本孟德尔随机化框架中利用与咖啡因代谢相关的遗传变异来研究血浆咖啡因水平对阿尔茨海默病和帕金森病风险的影响。结果的遗传关联估计来自国际阿尔茨海默氏症基因组学项目、国际帕金森氏症基因组学联盟、FinnGen 联盟和英国生物银行。基因预测较高的血浆咖啡因水平与阿尔茨海默氏病的风险较低（优势比 0.87；95% 置信区间 0.76、1.00；p = 0.056）相关。 FinnGen 联盟观察到，基因预测的血浆咖啡因水平较高与帕金森病风险较低之间存在暗示性关联。但不属于国际帕金森病基因组学联盟；未发现总体关联（优势比 0.92；95% 置信区间 0.77、1.10；p = 0.347）。这项研究发现了咖啡因对阿尔茨海默病具有保护作用的可能暗示证据。咖啡因与帕金森病之间的关联需要进一步研究。
We leveraged genetic variants associated with caffeine metabolism in the two-sample Mendelian randomization framework to investigate the effect of plasma caffeine levels on the risk of Alzheimer’s disease and Parkinson’s disease. Genetic association estimates for the outcomes were obtained from the International Genomics of Alzheimer’s Project, the International Parkinson’s Disease Genomics consortium, the FinnGen consortium, and the UK Biobank. Genetically predicted higher plasma caffeine levels were associated with a non-significant lower risk of Alzheimer’s disease (odds ratio 0.87; 95% confidence interval 0.76, 1.00; p = 0.056). A suggestive association was observed for genetically predicted higher plasma caffeine levels and lower risk of Parkinson’s disease in the FinnGen consortium. but not in the International Parkinson’s Disease Genomics consortium; no overall association was found (odds ratio 0.92; 95% confidence interval 0.77, 1.10; p = 0.347). This study found possible suggestive evidence of a protective role of caffeine in Alzheimer’s disease. The association between caffeine and Parkinson’s disease requires further study.
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影响因子：
3.9
作者：
Avitan I;Halperin Y;Saha T;Bloch N;Atrahimovich D;Polis B;Samson AO;Braitbard O
通讯作者：
Braitbard O
影响因子：
5.9
作者：
Larsson SC;Orsini N
通讯作者：
Orsini N
影响因子：
6.1
作者：
Rivera-Oliver, Marla;Diaz-Rios, Manuel
通讯作者：
Diaz-Rios, Manuel
影响因子：
30.8
作者：
Kunkle, Brian W.;Grenier-Boley, Benjamin;Pericak-Vance, Margaret A.
通讯作者：
Pericak-Vance, Margaret A.
影响因子：
4.8
作者：
Gardener SL;Rainey-Smith SR;Villemagne VL;Fripp J;Doré V;Bourgeat P;Taddei K;Fowler C;Masters CL;Maruff P;Rowe CC;Ames D;Martins RN;AIBL Investigators
通讯作者：
AIBL Investigators