CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.
CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.
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CD27是干扰素 - 粉状和白介素17产生的伽玛德氏菌T细胞亚群之间平衡的胸腺决定因素。
作者：
αβ 和 γδ T 细胞产生的细胞因子（例如干扰素 γ 和白细胞介素 17）会影响免疫反应的结果。在这里，我们发现大多数γδ T淋巴细胞表达肿瘤坏死因子受体家族成员CD27并分泌干扰素-γ，而白细胞介素17的产生仅限于CD27-γδ T细胞。与 αβ T 细胞明显的可塑性相反，这些不同的 γδ T 细胞亚群的细胞因子谱基本稳定，即使在感染期间也是如此。这些表型是在胸腺发育过程中建立的，此时 CD27 至少部分通过诱导淋巴毒素-β 受体以及与反式调节和干扰素-γ 产生相关的基因的表达来发挥 γδ T 细胞分化调节剂的作用。因此，外周γδ T细胞的细胞因子谱主要由涉及CD27的机制预先确定。
The production of cytokines such as interferon-γ and interleukin 17 by αβ and γδ T cells influences the outcome of immune responses. Here we show that most γδ T lymphocytes expressed the tumor necrosis factor receptor family member CD27 and secreted interferon-γ, whereas interleukin 17 production was restricted to CD27- γδ T cells. In contrast to the apparent plasticity of αβ T cells, the cytokine profiles of these distinct γδ T cell subsets were essentially stable, even during infection. These phenotypes were established during thymic development, when CD27 functions as a regulator of the differentiation of γδ T cells at least in part by inducing expression of the lymphotoxin-β receptor and genes associated with trans-conditioning and interferon-γ production. Thus, the cytokine profiles of peripheral γδ T cells are predetermined mainly by a mechanism involving CD27.
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