Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome.
Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome.
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DOI：
10.1111/jcmm.15883
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发表时间：
2020-11
影响因子：
5.3
通讯作者：
Baban B
中科院分区：
文献类型：
--
作者：
Salles ÉL;Khodadadi H;Jarrahi A;Ahluwalia M;Paffaro VA Jr;Costigliola V;Yu JC;Hess DC;Dhandapani KM;Baban B
鉴于新冠肺炎缺乏针对性的抗病毒治疗和疫苗接种，因此迫切需要一种有效的治疗方法来减少住院和死亡率，并改善新冠肺炎感染患者的预后。在我们最近发现大麻二醇(CBD)治疗急性呼吸窘迫综合征(ARDS)的潜力的后续研究中，我们首次表明CBD可以通过上调apelin来改善ARDS的症状，apelin是一种在免疫、中枢神经系统、代谢和心血管系统的中枢和外周调节中具有重要作用的多肽。通过鼻腔注射Poly(I：C)，一种合成的病毒dsRNA，虽然我们能够在小鼠模型中模拟ARDS的症状，但有趣的是，血液和肺组织中apelin的表达都显著减少。CBD治疗能使ARDS的症状恢复到正常水平。重要的是，CBD治疗显著增加了apelin的表达，提示apeline能系统与CBD之间的潜在串扰可能是治疗炎症性疾病如新冠肺炎和许多其他病理条件的治疗靶点。
Considering lack of target‐specific antiviral treatment and vaccination for COVID‐19, it is absolutely exigent to have an effective therapeutic modality to reduce hospitalization and mortality rate as well as to improve COVID‐19‐infected patient outcomes. In a follow‐up study to our recent findings indicating the potential of Cannabidiol (CBD) in the treatment of acute respiratory distress syndrome (ARDS), here we show for the first time that CBD may ameliorate the symptoms of ARDS through up‐regulation of apelin, a peptide with significant role in the central and peripheral regulation of immunity, CNS, metabolic and cardiovascular system. By administering intranasal Poly (I:C), a synthetic viral dsRNA, while we were able to mimic the symptoms of ARDS in a murine model, interestingly, there was a significant decrease in the expression of apelin in both blood and lung tissues. CBD treatment was able to reverse the symptoms of ARDS towards a normal level. Importantly, CBD treatment increased the apelin expression significantly, suggesting a potential crosstalk between apelinergic system and CBD may be the therapeutic target in the treatment of inflammatory diseases such as COVID‐19 and many other pathologic conditions.
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DOI：
10.1007/978-981-15-4814-7_1
发表时间：
2020-04-30
期刊：
Coronavirus Disease 2019 (COVID-19)
影响因子：
--
作者：
Saxena SK;Kumar S;Maurya VK;Sharma R;Dandu HR;Bhatt ML
通讯作者：
Bhatt ML
DOI：
10.1016/s0167-4889(00)00143-9
发表时间：
2001-04-23
影响因子：
5.1
作者：
Kawamata, Y;Fukusumi, S;Fujino, M
通讯作者：
Fujino, M
影响因子：
3.8
作者：
Nichols, James M.;Kaplan, Barbara L. F.
通讯作者：
Kaplan, Barbara L. F.
影响因子：
5.8
作者：
Stowell NC;Seideman J;Raymond HA;Smalley KA;Lamb RJ;Egenolf DD;Bugelski PJ;Murray LA;Marsters PA;Bunting RA;Flavell RA;Alexopoulou L;San Mateo LR;Griswold DE;Sarisky RT;Mbow ML;Das AM
通讯作者：
Das AM
影响因子：
7.3
作者：
Esposito, Giuseppe;Pesce, Marcella;Sarnelli, Giovanni
通讯作者：
Sarnelli, Giovanni