In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: Repeatability and reproducibility.
In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: Repeatability and reproducibility.
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DOI：
10.1016/j.jbiomech.2021.110427
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发表时间：
2021-05-24
影响因子：
2.4
通讯作者：
Twa MD
中科院分区：
文献类型：
--
作者：
Lan G;Aglyamov S;Larin KV;Twa MD
可靠、定量的角膜生物力学评价对于角膜疾病的检测和治疗具有重要意义。本研究评估了一种新的基于光学相干断层扫描(OCT)的弹性成像(OCE)方法的重复性和重复性，该方法用于在体定量测量20只正常人眼的角膜固有频率。在1-6.25mm2的测量区域附近，用重复的低力(13Pa.)微升空气脉冲在角膜顶端诱发亚微米级的角膜振荡，并通过共光路相敏OCT成像观察到。使用基于角膜振荡的单自由度模型来量化角膜固有频率。角膜固有频率2 34~2 77赫兹(变异系数：3.2%；2.5×2.5mm2范围内n=2 86；时间：2 8.6 S)。用较小的采样量(1 mm~2，n=9)和较短的时间(0.9 S)可以获得相同的固有频率。自然频率的空间分布和局部变化可以使用更密集的采样(例如，2.5×5mm2的26×41个点)来区分。这种新的光学方法证明了人体角膜自然频率的高度重复性和可靠性。虽然还需要进一步的研究来充分表征解剖学和结构上的相关性，但该方法可能是对现有的OCE方法的补充，该方法用于从基于应变或剪切波的测量中估计杨氏模量，以定量确定角膜生物力学。
Reliable and quantitative assessment of corneal biomechanics is important for the detection and treatment of corneal disease. The present study evaluates the repeatability and reproducibility of a novel optical coherence tomography (OCT)-based elastography (OCE) method for in vivo quantification of corneal natural frequency in 20 normal human eyes. Sub-micron corneal oscillations were induced by repeated low-force (13 Pa) microliter air pulses at the corneal apex and were observed by common-path phase-sensitive OCT imaging adjacent to a measurement region of 1–6.25 mm2. Corneal natural frequencies were quantified using a single degree of freedom model based on the corneal oscillations. Corneal natural frequencies ranged from 234 to 277 Hz (coefficient of variation: 3.2%; n = 286 for a 2.5 × 2.5 mm2 area; time: 28.6 s). The same natural frequencies can be acquired using a smaller sampling size (n = 9 for 1 mm2) and a shorter time (0.9 s). Spatial distribution and local changes in natural frequencies can be distinguished using denser sampling (e.g., 26 × 41 points for 2.5 × 5 mm2). This novel optical method demonstrates highly repeatable and reliable in vivo measurements of human corneal natural frequencies. While further studies are required to fully characterize anatomical and structural dependencies, this method may be complementary to the current OCE methods used to estímate Young’s modulus from strain- or shear-wave-based measurements for the quantitative determination of corneal biomechanics.
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影响因子：
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作者：
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