Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats.
Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats.
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DOI：
10.1038/srep01763
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发表时间：
2013
影响因子：
4.6
通讯作者：
Shido, Osamu
中科院分区：
文献类型：
--
作者：
Sugimoto, Naotoshi;Matsuzaki, Kentaro;Ishibashi, Hiroaki;Tanaka, Masao;Sawaki, Toshioki;Fujita, Yoshimasa;Kawanami, Takafumi;Masaki, Yasufumi;Okazaki, Toshiro;Sekine, Joji;Koizumi, Shoichi;Yachie, Akihiro;Umehara, Hisanori;Shido, Osamu
已知水通道蛋白(AQP)5在唾液腺腺泡细胞顶膜上的表达对啮齿动物和人类的唾液分泌具有重要作用。虽然热习服促进了啮齿类动物的唾液分泌，但热如何诱导唾液分泌的分子机制尚未确定。在这里，我们发现热习服增强了大鼠颌下腺中AQP5和AQP1的表达，同时促进了HIF-1α通路，导致了血管内皮生长因子的诱导和CD31阳性的血管生成。热习服后AQP5在浆液性腺泡细胞的顶膜分布增强，而AQP1仅表达于颌下腺的内皮细胞。水通道蛋白网络可能参与唾液分泌的热习服调节。由于水通道蛋白可能在人类唾液分泌中起关键作用，这些发现可能导致治疗唾液分泌不足的新策略。
It is known that aquaporin (AQP) 5 expression in the apical membrane of acinar cells in salivary glands is important for the secretion of saliva in rodents and humans. Although heat acclimation enhances saliva secretion in rodents, the molecular mechanism of how heat induces saliva secretion has not been determined. Here, we found that heat acclimation enhanced the expression of AQP5 and AQP1 in rat submandibular glands concomitant with the promotion of the HIF-1α pathway, leading to VEGF induction and CD31-positive angiogenesis. The apical membrane distribution of AQP5 in serous acinar cells enhanced after heat acclimation, while AQP1 expression was restricted to the endothelial cells in the submandibular glands. A network of AQPs may be involved in heat-acclimated regulation in saliva secretion. Because AQPs probably plays a crucial role in saliva secretion in humans, these findings may lead to a novel strategy for treating saliva hyposecretion.
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影响因子：
4.8
作者：
Ma, TH;Song, YL;Verkman, AS
通讯作者：
Verkman, AS
影响因子：
4.5
作者：
Akamatsu, T;Parvin, MN;Hosoi, K
通讯作者：
Hosoi, K
影响因子：
3.8
作者：
GISOLFI, CV;OWEN, MD;KREGEL, KC
通讯作者：
KREGEL, KC
DOI：
10.1006/bbrc.1997.7219
发表时间：
1997-08-28
影响因子：
3.1
作者：
Ishibashi, K;Kuwahara, M;Sasaki, S
通讯作者：
Sasaki, S
影响因子：
--
作者：
Farnaud SJ;Kosti O;Getting SJ;Renshaw D
通讯作者：
Renshaw D