Miniaturizing chemistry and biology using droplets in open systems.
Miniaturizing chemistry and biology using droplets in open systems.
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DOI：
10.1038/s41570-023-00483-0
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发表时间：
2023-06
影响因子：
36.3
通讯作者：
Theberge, Ashleigh B.
中科院分区：
文献类型：
--
作者：
Zeng, Yuting;Khor, Jian Wei;van Neel, Tammi L.;Tu, Wan-chen;Berthier, Jean;Thongpang, Sanitta;Berthier, Erwin;Theberge, Ashleigh B.
开放液滴微流体系统在开放环境中以皮升至微升的规模操纵液滴。它们将传统基于液滴的微流体提供的区室化和控制与开放式微流体的可访问性和易用性相结合，为组合反应，液滴分析和细胞培养等应用带来了独特的优势。开放式系统提供了对液滴的直接访问，并允许在系统内按需进行液滴操作，而无需泵或管，这使得生物学家无需复杂的设置即可访问系统。此外，这些系统可以通过简单的制造和组装步骤生产，从而允许大规模制造并将该方法转化为临床研究。本文介绍了不同类型的开放液滴微流控系统，提出了这些系统所利用的物理概念，并强调了关键的应用。开放液滴微流体系统具有独特的优势;例如，液滴是可访问的，并且该系统可以很好地转化为生物医学研究。本文重点介绍了化学和生物学中不同类型的开放液滴微流控系统，并讨论了它们的物理概念和关键应用。
Open droplet microfluidic systems manipulate droplets on the picolitre-to-microlitre scale in an open environment. They combine the compartmentalization and control offered by traditional droplet-based microfluidics with the accessibility and ease-of-use of open microfluidics, bringing unique advantages to applications such as combinatorial reactions, droplet analysis and cell culture. Open systems provide direct access to droplets and allow on-demand droplet manipulation within the system without needing pumps or tubes, which makes the systems accessible to biologists without sophisticated setups. Furthermore, these systems can be produced with simple manufacturing and assembly steps that allow for manufacturing at scale and the translation of the method into clinical research. This Review introduces the different types of open droplet microfluidic system, presents the physical concepts leveraged by these systems and highlights key applications. Open droplet microfluidic systems have unique advantages; for example, the droplets are accessible and the systems translate well into biomedical research. This Review highlights different types of open droplet microfluidic system in chemistry and biology and discusses their physical concepts and key applications.
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影响因子：
6.1
作者：
de Groot TE;Veserat KS;Berthier E;Beebe DJ;Theberge AB
通讯作者：
Theberge AB
用于生物传感的具有定向液滴传输功能的仿生超可湿性微脊柱芯片
影响因子：
17.1
作者：
Chen, Yanxia;Li, Kan;Zhang, Xueji
通讯作者：
Zhang, Xueji
影响因子：
16.6
作者：
Benz, Maximilian;Molla, Mijanur R.;Levkin, Pavel A.
通讯作者：
Levkin, Pavel A.
DOI：
10.1073/pnas.1704020114
发表时间：
2017-08-15
影响因子：
11.1
作者：
Cole, Russell H.;Tang, Shi-Yang;Abate, Adam R.
通讯作者：
Abate, Adam R.
影响因子：
46.9
作者：
Bhatia, Sangeeta N.;Ingber, Donald E.
通讯作者：
Ingber, Donald E.