Tumor-associated macrophages, potential targets for cancer treatment.

Tumor-associated macrophages, potential targets for cancer treatment.
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肿瘤相关巨噬细胞,癌症治疗的潜在靶点

DOI:
10.1186/s40364-017-0106-7
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发表时间:
2017
期刊:
影响因子:
11.1
通讯作者:
Zhang Y
Zhang Y
中科院分区:
医学2区
文献类型:
--
作者:
Yang L;Zhang Y

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在肿瘤组织中可以发现各种免疫细胞,包括巨噬细胞,这一事实早已为人所知。随着巨噬细胞分化为经典或替代活化表型的概念的引入,肿瘤相关巨噬细胞(TAMs)的作用现在开始被阐明。TAM充当“促肿瘤巨噬细胞”,促进疾病进展。随着TAM与恶性肿瘤之间的关系变得更加清晰,TAM开始被视为这些病例中的潜在治疗靶点。本文就TAMs作为肿瘤治疗靶点的临床应用作一综述。
The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages”, contributing to disease progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential therapeutic targets in these cases. In this review, we will discuss how TAMs can be used as therapeutic targets of cancer in clinics.
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