Tumor-associated macrophages, potential targets for cancer treatment.
Tumor-associated macrophages, potential targets for cancer treatment.
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肿瘤相关巨噬细胞,癌症治疗的潜在靶点
DOI:
10.1186/s40364-017-0106-7
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发表时间:
2017
影响因子:
11.1
通讯作者:
Zhang Y
中科院分区:
文献类型:
--
作者:
Yang L;Zhang Y
The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages”, contributing to disease progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential therapeutic targets in these cases. In this review, we will discuss how TAMs can be used as therapeutic targets of cancer in clinics.
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