Measuring salivary markers of inflammation in health research: A review of methodological considerations and best practices.
Measuring salivary markers of inflammation in health research: A review of methodological considerations and best practices.
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DOI：
10.1016/j.psyneuen.2020.105069
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发表时间：
2021-03
影响因子：
3.7
通讯作者：
Slavish DC
中科院分区：
文献类型：
--
作者：
Szabo YZ;Slavish DC
人们对使用唾液测量炎症生物标志物的兴趣越来越大。与血液相比，唾液是非侵入性的，需要较低的生物安全分类，需要较少的专业人员来收集。随着唾液中炎症的评估在心理神经免疫学研究中变得越来越流行，金标准方法实践的发展至关重要。本文综述了不同的考虑设计的研究，以评估唾液炎症的措施。我们回顾唾液收集程序，样本储存和处理的考虑，分析技术，流速，对应于血液为基础的标记物，和潜在的人口和健康的调节剂水平的唾液炎症标记物。总之，这篇综述强调了未来研究的关键差距，包括要求研究方案标准化，结果的透明报告，评估唾液炎症标志物对疾病的预测有效性，以及评估参与者口腔和一般健康状况的必要性。虽然需要更多的工作来阐明研究设计，测量和分析的金标准，但唾液炎症标志物可能是非侵入性了解口腔和外周炎症动力学的有用工具。
There is an increasing interest in using saliva to measure inflammatory biomarkers. Compared to blood, saliva is non-invasive, requires a lower biosafety classification, and requires less specialized personnel to collect. As the assessment of inflammation in saliva becomes more popular in psychoneuroimmunology research, the development of gold-standard methodological practices is paramount. This paper reviews different considerations for designing studies to assess salivary measures of inflammation. We review saliva collection procedures, sample storage and processing considerations, assay techniques, flow rate, correspondence with blood-based markers, and potential demographic and health moderators of levels of salivary markers of inflammation. Together, this review highlights critical gaps for future research, including calls for standardization of study protocols, transparent reporting of results, assessing predictive validity of markers of salivary inflammation for disease, and the need for assessment of participants’ oral and general health status. Although additional work is needed to elucidate gold standards for study design, measurement, and analysis, salivary markers of inflammation may be a useful tool for understanding oral and peripheral inflammation dynamics non-invasively.
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影响因子：
3.5
作者：
Ebersole JL;Kryscio RJ;Campbell C;Kinane DF;McDevitt J;Christodoulides N;Floriano PN;Miller CS
通讯作者：
Miller CS
影响因子：
2.8
作者：
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作者：
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影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
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DOI：
10.1034/j.1600-0528.2002.00014.x
发表时间：
2002-12-01
影响因子：
2.3
作者：
Buhlin, K;Gustafsson, A;Klinge, B
通讯作者：
Klinge, B