Characterizing the gut microbiome changes with aging in a novel Alzheimer's disease rat model.
Characterizing the gut microbiome changes with aging in a novel Alzheimer's disease rat model.
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DOI：
10.18632/aging.204484
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发表时间：
2023-01-13
期刊：
影响因子：
5.2
通讯作者：
Sun, Liou Y.
中科院分区：
文献类型：
--
作者：
Nagarajan, Akash;Srivastava, Hemant;Morrow, Casey D.;Sun, Liou Y.
阿尔茨海默病（AD）是目前世界上最具破坏性的疾病之一，没有有效的治疗方法。越来越多的证据表明，肠道微生物组在AD中发挥作用。在这里，我们着手研究Tgf 344-AD大鼠的微生物组中与年龄相关的变化。我们对14和20月龄雄性大鼠的粪便样本进行了16 S核糖体RNA测序。我们发现Tgf 344-AD大鼠在14月龄时与对照组相比微生物多样性降低，而在20月龄时发现情况相反。有趣的是，我们发现随着年龄的增长，大鼠的微生物群落结构发生了明显的变化，沿着微生物群组成的变化。在Tgf 344 AD大鼠中观察到的一些变化是双歧杆菌属、瘤胃球菌属、副苏氏菌属、毛梭菌属和丁酸球菌属。Tgf 344-AD和WT对照组大鼠中发生的其他年龄相关变化为肠杆菌、志贺氏埃希菌、罗氏菌减少以及Turicibacter和Clostrium_senso_stricto增加。我们的研究表明，在这种阿尔茨海默病大鼠模型中发生了肠道微生物群的变化。
Alzheimer’s disease (AD) is one of the most devastating diseases currently in the world with no effective treatments. There is increasing evidence that the gut microbiome plays a role in AD. Here we set out to study the age-related changes in the microbiome of the Tgf344-AD rats. We performed 16S ribosomal RNA sequencing on the fecal samples of male rats at 14 and 20 months of age. We found the Tgf344-AD rats to have decreased microbial diversity compared to controls at 14 months of age and this was found to be opposite at 20 months of age. Interestingly, we found a distinctive shift in the microbial community structure of the rats with aging along with changes in the microbiota composition. Some of the observed changes in the Tgf344AD rats were in the genera Bifidobacterium, Ruminococcus, Parasutterella, Lachnoclostridium and Butyricicoccus. Other age-related changes occuring in both the Tgf344-AD and WT control rats were decreases in Enterohaldus, Escherichia Shigella, Rothia and increase in Turicibacter and Clostrium_senso_stricto. Our study has shown that gut microbiota changes occurs in this Alzheimer’s disease rat model.
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