Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake.
Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake.
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DOI：
10.1038/s41593-017-0014-z
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发表时间：
2017-12
影响因子：
25
通讯作者：
Palmiter RD
中科院分区：
文献类型：
--
作者：
Ryan PJ;Ross SI;Campos CA;Derkach VA;Palmiter RD
调节液体饱足的脑区还没有很好的表征，但对于理解液体稳态是必不可少的。我们发现，小鼠臂旁核中的催产素受体表达神经元（OxtrPBN神经元）是液体饱足的关键调节因子。OxtrPBN神经元的化学发生激活强烈抑制无热量的液体摄入，但并没有减少禁食后的食物摄入或盐消耗后的盐摄入;失活增加脱水和高渗盐水注射后的盐水摄入。在生理条件下，OxtrPBN神经元被液体饱和和高渗盐水注射激活。OxtrPBN神经元直接由室旁下丘脑中的催产素神经元（OxtPVH神经元）支配，其轻度减弱液体摄入。激活孤束核中的神经元实质上抑制了液体摄入并激活了OxtrPBN神经元。我们的研究结果表明，OxtrPBN神经元作为一个关键节点的流体饱和神经回路，其作用是减少水和/或盐水的摄入量，以防止或减轻血容量过多和高钠血症。作者表明，臂旁核中的催产素受体表达神经元是液体稳态的关键调节因子，在激活时抑制液体摄入，但不会减少禁食后的食物摄入或盐耗尽后的盐摄入。
Brain regions that regulate fluid satiation are not well characterized, yet are essential for understanding fluid homeostasis. We found that oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (OxtrPBN neurons) are key regulators of fluid satiation. Chemogenetic activation of OxtrPBN neurons robustly suppressed noncaloric fluid intake, but did not decrease food intake after fasting or salt intake following salt depletion; inactivation increased saline intake after dehydration and hypertonic saline injection. Under physiological conditions, OxtrPBN neurons were activated by fluid satiation and hypertonic saline injection. OxtrPBN neurons were directly innervated by oxytocin neurons in the paraventricular hypothalamus (OxtPVH neurons), which mildly attenuated fluid intake. Activation of neurons in the nucleus of the solitary tract substantially suppressed fluid intake and activated OxtrPBN neurons. Our results suggest that OxtrPBN neurons act as a key node in the fluid satiation neurocircuitry, which acts to decrease water and/or saline intake to prevent or attenuate hypervolemia and hypernatremia. The authors show that oxytocin-receptor-expressing neurons in the parabrachial nucleus are key regulators of fluid homeostasis that suppress fluid intake when activated, but do not decrease food intake after fasting or salt intake after salt depletion.
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DOI：
10.1152/ajpregu.1996.270.2.r427
发表时间：
1996-02-01
影响因子：
2.8
作者：
Huang, W;Lee, SL;Sjoquist, N
通讯作者：
Sjoquist, N
DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
2.9
作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
通讯作者：
BERTOLINI, A
影响因子：
3.3
作者：
Davern, P. J.;McKinley, M. J.
通讯作者：
McKinley, M. J.
DOI：
10.1111/j.1440-1681.1996.tb02594.x
发表时间：
1996-02-01
影响因子：
2.9
作者：
Johnson, AK;Cunningham, JT;Thunhorst, RL
通讯作者：
Thunhorst, RL