Relationships between brain and body temperature, clinical and imaging outcomes after ischemic stroke.
Relationships between brain and body temperature, clinical and imaging outcomes after ischemic stroke.
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DOI：
10.1038/jcbfm.2013.52
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发表时间：
2013-07
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中风后不久的发热与严重中风和功能不良结果相关。很少有研究评估中风后患者的脑温度，因此对其与体温、中风严重程度或结果的关系知之甚少。我们使用 1H 磁共振波谱测量了缺血和正常大脑的温度，及其与每 4 小时测量一次的体温（鼓膜）温度、5 天的梗塞生长情况、早期神经系统（美国国立卫生研究院卒中量表，NIHSS）和晚期功能结果（死亡或依赖性）的相关性。在 40 名患者中（平均年龄 73 岁，中位 NIHSS 7 级，中位 17 小时成像），入院时缺血脑部的温度高于正常大脑（核心温度 38.6°C，对侧半球 37.9°C，P=0.03），但 5 天后两者的升高程度相同；两者均高于鼓室温度。缺血性病变温度与 NIHSS 或 3 个月功能结果无关；相反，较高的对侧正常脑温度与较差的 NIHSS、梗塞扩张和较差的功能结果相关，类似于鼓室温度的相关性。我们得出结论：大脑温度高于体温；缺血性脑部温度升高反映了局部组织对缺血的反应，而发热则反映了对中风的全身反应，发生较晚，并与不良后果相关。
Pyrexia soon after stroke is associated with severe stroke and poor functional outcome. Few studies have assessed brain temperature after stroke in patients, so little is known of its associations with body temperature, stroke severity, or outcome. We measured temperatures in ischemic and normal-appearing brain using 1H-magnetic resonance spectroscopy and its correlations with body (tympanic) temperature measured four-hourly, infarct growth by 5 days, early neurologic (National Institute of Health Stroke Scale, NIHSS) and late functional outcome (death or dependency). Among 40 patients (mean age 73 years, median NIHSS 7, imaged at median 17 hours), temperature in ischemic brain was higher than in normal-appearing brain on admission (38.6°C-core, 37.9°C-contralateral hemisphere, P=0.03) but both were equally elevated by 5 days; both were higher than tympanic temperature. Ischemic lesion temperature was not associated with NIHSS or 3-month functional outcome; in contrast, higher contralateral normal-appearing brain temperature was associated with worse NIHSS, infarct expansion and poor functional outcome, similar to associations for tympanic temperature. We conclude that brain temperature is higher than body temperature; that elevated temperature in ischemic brain reflects a local tissue response to ischemia, whereas pyrexia reflects the systemic response to stroke, occurs later, and is associated with adverse outcomes.
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影响因子：
6
作者：
den Hertog HM;van der Worp HB;van Gemert HM;Algra A;Kappelle LJ;van Gijn J;Koudstaal PJ;Dippel DW
通讯作者：
Dippel DW
DOI：
10.1159/000091706
发表时间：
2006-01-01
期刊：
Cerebrovascular diseases (Basel, Switzerland)
影响因子：
--
作者：
Castellanos, Mar;Sobrino, Tomas;Castillo, Jose
通讯作者：
Castillo, Jose
影响因子：
2.6
作者：
Karaszewski B;Thomas RG;Dennis MS;Wardlaw JM
通讯作者：
Wardlaw JM
影响因子：
2.5
作者：
Marshall, Ian;Karaszewski, Bartosz;Haga, Kristin
通讯作者：
Haga, Kristin
DOI：
10.1007/bf02668650
发表时间：
2001-08-01
影响因子：
2.3
作者：
Germain, D;Chevallier, P;Saint-Jalmes, H
通讯作者：
Saint-Jalmes, H