Guidelines for measuring cardiac physiology in mice.
Guidelines for measuring cardiac physiology in mice.
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DOI:
10.1152/ajpheart.00339.2017
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发表时间:
2018-04-01
期刊:
影响因子:
--
通讯作者:
Scherrer-Crosbie M
中科院分区:
文献类型:
--
作者:
Lindsey ML;Kassiri Z;Virag JAI;de Castro Brás LE;Scherrer-Crosbie M
Cardiovascular disease is a leading cause of death, and translational research is needed to understand better mechanisms whereby the left ventricle responds to injury. Mouse models of heart disease have provided valuable insights into mechanisms that occur during cardiac aging and in response to a variety of pathologies. The assessment of cardiovascular physiological responses to injury or insult is an important and necessary component of this research. With increasing consideration for rigor and reproducibility, the goal of this guidelines review is to provide best-practice information regarding how to measure accurately cardiac physiology in animal models. In this article, we define guidelines for the measurement of cardiac physiology in mice, as the most commonly used animal model in cardiovascular research. Listen to this article’s corresponding podcast at http://ajpheart.podbean.com/e/guidelines-for-measuring-cardiac-physiology-in-mice/.
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