Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study.
Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study.
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DOI：
10.1016/j.biopsych.2018.09.010
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发表时间：
2019-03-01
影响因子：
10.6
通讯作者：
Howes OD
中科院分区：
文献类型：
--
作者：
McCutcheon RA;Nour MM;Dahoun T;Jauhar S;Pepper F;Expert P;Veronese M;Adams RA;Turkheimer F;Mehta MA;Howes OD
从精神分裂症到药物成瘾，一系列神经精神疾病都涉及中脑边缘多巴胺系统和皮层显著性网络的异常。这两个系统在检测行为相关的环境刺激中起着关键作用。虽然存在解剖学重叠，但这些系统之间的功能关系仍然未知。临床前研究表明，中脑边缘多巴胺神经元的放电可能会激活显着性网络的节点，但鉴于该网络的物种特异性，需要进行体内人体研究。我们采用正电子发射断层扫描来测量腹侧纹状体内的多巴胺释放能力（使用D23受体配体11 C-PHNO，n = 23）和多巴胺合成能力（使用18F-DOPA，n = 21）。静息状态下的功能磁共振成像也进行了调查的显着性网络的功能连接在同一个人。一个图论的方法被用来描述多巴胺的措施和网络连接之间的关系。多巴胺的合成能力与更大的显着网络连接有关，这种关系在充当信息处理中心的大脑区域尤为明显。相比之下，多巴胺释放能力与较弱的显着网络连接。多巴胺测量与视觉和感觉运动网络之间没有关系，表明研究结果的特异性。我们的研究结果表明，显着性网络和中脑边缘多巴胺系统之间的密切关系，他们是相关的神经精神疾病，其中两个系统的异常功能已被观察到。
A wide range of neuropsychiatric disorders, from schizophrenia to drug addiction, involve abnormalities in both the mesolimbic dopamine system and the cortical salience network. Both systems play a key role in the detection of behaviorally relevant environmental stimuli. Although anatomical overlap exists, the functional relationship between these systems remains unknown. Preclinical research has suggested that the firing of mesolimbic dopamine neurons may activate nodes of the salience network, but in vivo human research is required given the species-specific nature of this network. We employed positron emission tomography to measure both dopamine release capacity (using the D2/3 receptor ligand 11C-PHNO, n = 23) and dopamine synthesis capacity (using 18F-DOPA, n = 21) within the ventral striatum. Resting-state functional magnetic resonance imaging was also undertaken in the same individuals to investigate salience network functional connectivity. A graph theoretical approach was used to characterize the relationship between dopamine measures and network connectivity. Dopamine synthesis capacity was associated with greater salience network connectivity, and this relationship was particularly apparent for brain regions that act as information-processing hubs. In contrast, dopamine release capacity was associated with weaker salience network connectivity. There was no relationship between dopamine measures and visual and sensorimotor networks, indicating specificity of the findings. Our findings demonstrate a close relationship between the salience network and mesolimbic dopamine system, and they are relevant to neuropsychiatric illnesses in which aberrant functioning of both systems has been observed.
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