Can healthy lifestyle reduce disease progression of Alzheimer's during a global pandemic of COVID-19?
Can healthy lifestyle reduce disease progression of Alzheimer's during a global pandemic of COVID-19?
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在 COVID-19 全球大流行期间，健康的生活方式能否减少阿尔茨海默病的进展？
DOI：
10.1016/j.arr.2021.101406
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发表时间：
2021-09
影响因子：
13.1
通讯作者：
Reddy PH
中科院分区：
文献类型：
--
作者：
John A;Ali K;Marsh H;Reddy PH
2019 年新型冠状病毒病 (COVID-19) 已将医疗系统推向崩溃的边缘。尽管该病毒一视同仁，但老年人和患有高血压、严重肥胖、糖尿病、冠心病、肺炎和痴呆等合并症的人因 COVID-19 而面临更大的不良后果风险。尽管许多人正在适应新常态，但大流行可能会产生什么长期影响的问题仍然存在。为了调查弱势群体如何受到这一流行病的影响，我们重点研究了阿尔茨海默病，这是一种了解该病毒如何影响 AD 进展和衰老风险的媒介。通过评估 COVID-19 对 AD 患者的影响，我们探索了 COVID-19 和阿尔茨海默病中的遗传、代谢和生活方式因素，这些因素可以协同作用，导致不良后果。本文还讨论了与年龄相关的病症和/或与年龄相关的合并症如何容易感染 COVID-19。我们还讨论了现在和未来可能减少和/或对抗 COVID-19 的健康生活方式因素。
The novel coronavirus disease 2019 (COVID-19) has pushed the medical system to its breaking point. While the virus does not discriminate, the elderly and those with comorbidities, including hypertension severe obesity, diabetes mellitus, coronary disease, pneumonia and dementia, are at a greater risk for adverse outcomes due to COVID-19. While many people navigate their new normal, the question of what the long-lasting effects of the pandemic may be, lingers. To investigate how vulnerable populations are affected by the pandemic, we focused on Alzheimer’s disease, a vector to understanding how the virus has impacted AD progression and risk via aging. By assessing the effect of COVID-19 on AD patients, we explore genetics, metabolism, and lifestyle factors in both COVID-19 and Alzheimer’s disease that can work synergistically to precipitate adverse outcomes. This article also discusses how age-related conditions and/or age-related comorbidities susceptible to COVID-19. We also discuss possible healthy lifestyle factors reduce and/or combat COVID-19 now and in the future.
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DOI：
10.3390/healthcare8030286
发表时间：
2020-08-21
期刊：
Healthcare (Basel, Switzerland)
影响因子：
--
作者：
Abate G;Memo M;Uberti D
通讯作者：
Uberti D
DOI：
10.1177/1470320320908186
发表时间：
2020-01-01
影响因子：
2.9
作者：
Cohall, Damian;Ojeh, Nkemcho;Nunez-Smith, Marcella
通讯作者：
Nunez-Smith, Marcella
影响因子：
4.8
作者：
Jan AT;Azam M;Rahman S;Almigeiti AMS;Choi DH;Lee EJ;Haq QMR;Choi I
通讯作者：
Choi I
影响因子：
2.1
作者：
Gilsanz P;Mayeda ER;Glymour MM;Quesenberry CP Jr;Mungas D;DeCarli CS;Whitmer RA
通讯作者：
Whitmer RA
影响因子：
--
作者：
Fitzpatrick, Annette L.;Kuller, Lewis H.;Lopez, Oscar L.;Diehr, Paula;O'Meara, Ellen S.;Longstreth, W. T., Jr.;Luchsinger, Jose A.
通讯作者：
Luchsinger, Jose A.