Maternal influences over offspring allergic responses.

Maternal influences over offspring allergic responses.
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DOI:
10.1007/s11882-014-0501-1
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发表时间:
2015-02
影响因子:
5.5
通讯作者:
Cook-Mills, Joan M.
Cook-Mills, Joan M.
中科院分区:
医学2区
文献类型:
--
作者:
Cook-Mills, Joan M.

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Asthma occurs as a result of complex interactions of environmental and genetic factors. Clinical studies and animal models of asthma indicate offspring of allergic mothers have increased risk of development of allergies. Environmental factors including stress-induced corticosterone and vitamin E isoforms during pregnancy regulate the risk for offspring development of allergy. In this review, we discuss mechanisms for the development of allergic disease early in life, environmental factors that may impact the development of risk for allergic disease early in life, and how the variation in global prevalence of asthma may be explained, at least in part, by some environmental components.
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