Improving the heating efficiency of high intensity focused ultrasound ablation through the use of phase change nanodroplets and multifocus sonication.
Improving the heating efficiency of high intensity focused ultrasound ablation through the use of phase change nanodroplets and multifocus sonication.
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DOI：
10.1088/1361-6560/ab9559
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发表时间：
2020-10-12
影响因子：
3.5
通讯作者：
Caskey C
中科院分区：
文献类型：
--
作者：
Singh A;Nyankima AG;Anthony Phipps M;Chaplin V;Dayton PA;Caskey C
超声波热消融是治疗软组织癌症的一种局部治疗方法，例如肝癌或乳腺癌。这些治疗的一个挑战是非目标效应，包括在预定区域外加热或皮肤灼伤。加热效率的提高可以缓解这些不良后果，在这里，我们描述了使用相移纳米液滴(PSND)与多聚焦超声相结合的方法，在恒定功率下提高体积烧蚀和烧蚀效率，同时将预焦温度提高不到6°C。4个焦点的多聚焦烧蚀效果最好，平均烧蚀体积为120.2±22.4mm3，烧蚀效率为0.04mm3/J，而单焦点情况下的烧蚀体积为61.2±21.16mm3，烧蚀效率为0.02mm3/J。本文提出的PSNDS与多焦点超声联合使用是一种在降低靶外效应的同时提高消融效率的新方法，可广泛应用于各种聚焦超声热消融治疗中。
Thermal ablation by ultrasound is being explored as a local therapy for cancers of soft tissue, such as the liver or breast. One challenge for these treatments are off-target effects, including heating outside of the intended region or skin burns. Improvements in heating efficiency can mitigate these undesired outcomes, and here, we describe methods for using phase-shift nanodroplets (PSNDs) with multi-focus sonications to enhance volumetric ablation and ablation efficiency at constant powers while increasing the pre-focal temperature by less than 6°C. Multi-focus ablation with 4 foci performed the best and achieved a mean ablation volume of 120.2±22.4 mm3 and ablation efficiency of 0.04 mm3/J vs an ablation volume of 61.2±21.16mm3 and ablation efficiency of 0.02 mm3/J in single foci case. The combined use of PSNDs with multi-focal ultrasound presented here is a new approach to increasing ablation efficiency while reducing off-target effects and could be generally applied in various focused ultrasound thermal ablation treatments.
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影响因子：
29.4
作者：
El-Serag HB
通讯作者：
El-Serag HB
影响因子：
5.9
作者：
Kaneko, Y;Maruyama, T;Matsumoto, Y
通讯作者：
Matsumoto, Y
影响因子：
--
作者：
Inoue M;Nakatsuka S;Jinzaki M
通讯作者：
Jinzaki M
DOI：
10.1109/58.31798
发表时间：
1989-09-01
影响因子：
3.6
作者：
EBBINI, ES
通讯作者：
EBBINI, ES
DOI：
10.1186/s40349-015-0029-4
发表时间：
2015
期刊：
Journal of therapeutic ultrasound
影响因子：
--
作者：
Moyer LC;Timbie KF;Sheeran PS;Price RJ;Miller GW;Dayton PA
通讯作者：
Dayton PA