Cochlear inflammaging: cellular and molecular players of the innate and adaptive immune system in age-related hearing loss.
Cochlear inflammaging: cellular and molecular players of the innate and adaptive immune system in age-related hearing loss.
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DOI：
10.3389/fneur.2023.1308823
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发表时间：
2023
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
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作者：
与听力损失相关的听力损失是世界上最常见的感觉障碍，导致老龄化人口的许多健康状况。尽管其流行，但目前的治疗，包括助听器，在改善听力缺陷或减缓或逆转其病理生理学方面并不令人满意。免疫衰老是神经退行性疾病的一个关键驱动因素，最近在与年龄相关的听力损失中也有类似的机制受到关注。细胞因子和趋化因子的不平衡水平有助于异常的免疫细胞活性和慢性促炎微环境，这可能导致内耳结构和功能的退化。巨噬细胞，通常是器官稳态的监护人，被发现由于未识别的因素而随着年龄的增长而发展失调的活性，并且它们与先天免疫系统的其他组分相互作用以损害感觉毛细胞、突触、神经元和对感觉信号传递至关重要的内耳的其他结构。它们还越来越多地触发炎性体（一种参与炎性细胞死亡的蛋白质复合物）和补体级联反应，以使耳蜗中的炎症和细胞损伤循环永久化，从而导致听力损失。某些T细胞群的衰老也表明了适应性免疫在年龄相关性听力损失中的作用。破译免疫失调的机制是产生听力损失靶向治疗的关键第一步。这篇简短的综述描述了当前和新兴的研究，围绕先天性和适应性免疫系统在年龄相关性听力损失及其与其他神经退行性疾病的相似之处的失调。
Age-related hearing loss is the most common sensory disorder worldwide that contributes to numerous health conditions in the aging population. Despite its prevalence, current treatments, including hearing aids, are unsatisfactory in improving hearing deficits or slowing or reversing its pathophysiology. Immunosenescence is a key driver of neurodegenerative disease, and a similar mechanism has recently come to attention in age-related hearing loss. Imbalanced levels of cytokines and chemokines contribute to aberrant immune cell activity and a chronic pro-inflammatory microenvironment that may lead to degradation of inner ear structure and function. Macrophages, typically guardians of organ homeostasis, are found to develop dysregulated activity with aging due to unidentified factors, and they interact with other components of the innate immune system to damage sensory hair cells, synapses, neurons, and other structures of the inner ear critical to sensory signal transmission. They also increasingly trigger the inflammasome, a protein complex involved in inflammatory cell death, and the complement cascade, to perpetuate a cycle of inflammation and cellular damage in the cochlea, resulting in hearing loss. Senescence in certain T cell populations have indicated a role of adaptive immunity in age-related hearing loss as well. Deciphering the mechanisms of immune dysregulation is a critical first step in producing targeted therapies for hearing loss. This brief review describes the current and emerging research surrounding the dysregulation of the innate and adaptive immune systems in age-related hearing loss and its parallels with other neurodegenerative diseases.
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影响因子：
64.8
作者：
通讯作者：
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白介素-1受体中的遗传多态性与台湾人口突然的感觉性听力丧失的遗传多态性与一项案例控制研究。
DOI：
10.1186/s40463-021-00550-w
发表时间：
2021-12-05
期刊：
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
影响因子：
--
作者：
Chien CY;Tai SY;Li KH;Yang HL;Chan LP;Hsi E;Wang LF;Ho KY;Chang NC
通讯作者：
Chang NC
影响因子：
6
作者：
Bazard P;Pineros J;Frisina RD;Bauer MA;Acosta AA;Paganella LR;Borakiewicz D;Thivierge M;Mannering FL;Zhu X;Ding B
通讯作者：
Ding B
影响因子：
3.3
作者：
Kariya, S.;Okano, M.;Nishizaki, K.
通讯作者：
Nishizaki, K.
影响因子：
4.7
作者：
Cardona SM;Mendiola AS;Yang YC;Adkins SL;Torres V;Cardona AE
通讯作者：
Cardona AE