First in vivo traumatic brain injury imaging via magnetic particle imaging.

First in vivo traumatic brain injury imaging via magnetic particle imaging.
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DOI:
10.1088/1361-6560/aa52ad
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发表时间:
2017-05-07
影响因子:
3.5
通讯作者:
Conolly S
Conolly S
中科院分区:
工程技术2区
文献类型:
--
作者:
Orendorff R;Peck AJ;Zheng B;Shirazi SN;Matthew Ferguson R;Khandhar AP;Kemp SJ;Goodwill P;Krishnan KM;Brooks GA;Kaufer D;Conolly S

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由于创伤性脑损伤(TBI)急诊室就诊是常见的,但分类损伤的严重程度仍然是一个开放的挑战。一些主观的方法,如格拉斯哥昏迷量表,试图对创伤性脑损伤进行分类,以及一些基于成像的方式,如计算机断层扫描和磁共振成像。然而,到目前为止,仍然很难发现和监测轻中度损伤。在本报告中,我们证明了磁颗粒成像(MPI)模式可以应用于成像TBI事件,具有良好的对比度。MPI可以在没有信号丢失的情况下长时间监测注射的铁纳米颗粒,使研究人员和临床医生能够监测伤口愈合过程中血池的变化。
Emergency room visits due to Traumatic Brain Injury (TBI) is common, but classifying the severity of the injury remains an open challenge. Some subjective methods such as the Glasgow Coma Scale attempt to classify traumatic brain injuries, as well as some imaging based modalities such as computed tomography and magnetic resonance imaging. However, to date it is still difficult to detect and monitor mild to moderate injuries. In this report, we demonstrate that the magnetic particle imaging (MPI) modality can be applied to imaging TBI events with excellent contrast. MPI can monitor injected iron nanoparticles over long time scales without signal loss, allowing researchers and clinicians to monitor the change in blood pools as the wound heals.
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