Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration.

Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration.
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CXCR4 在伤口修复和再生中的多效性作用

DOI:
10.3389/fimmu.2021.668758
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发表时间:
2021
影响因子:
7.3
通讯作者:
Li B
Li B
中科院分区:
医学2区
文献类型:
--
作者:
Chen H;Li G;Liu Y;Ji S;Li Y;Xiang J;Zhou L;Gao H;Zhang W;Sun X;Fu X;Li B

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伤口愈合是一个多步骤的过程,包括多种细胞事件,例如细胞增殖、细胞粘附、趋化反应以及细胞凋亡。越来越多的研究已经证明了基质细胞衍生因子 1 (SDF-1)/C-X-C 趋化因子受体 4 (CXCR4) 信号在伤口修复和再生中的重要性。然而,再生的分子机制尚不清楚。这篇综述描述了 CXCR4 参与的各种类型的组织再生,以及如何通过 CXCR4 过表达来提高再生效率。它强调了 CXCR4 在再生中的多效性作用。通过深入研究CXCR4的具体分子机制,我们希望为组织工程和未来再生医学提供理论基础。
Wound healing is a multi-step process that includes multiple cellular events such as cell proliferation, cell adhesion, and chemotactic response as well as cell apoptosis. Accumulating studies have documented the significance of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4) signaling in wound repair and regeneration. However, the molecular mechanism of regeneration is not clear. This review describes various types of tissue regeneration that CXCR4 participates in and how the efficiency of regeneration is increased by CXCR4 overexpression. It emphasizes the pleiotropic effects of CXCR4 in regeneration. By delving into the specific molecular mechanisms of CXCR4, we hope to provide a theoretical basis for tissue engineering and future regenerative medicine.
DOI: 10.1038/nature17039
发表时间: 2016-01-21
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