A causal link between lymphopenia and autoimmunity.
A causal link between lymphopenia and autoimmunity.
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DOI：
10.1016/j.imlet.2004.10.022
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发表时间：
2005-04-15
影响因子：
4.4
通讯作者：
Fraser JM
中科院分区：
文献类型：
--
作者：
Khoruts A;Fraser JM
众所周知，成熟T细胞群体的组成受到严格的动态平衡控制。各种T细胞亚群的TCR谱系和相对比例在胸腺中建立，并在外周继续被塑造和调节。随着胸腺功能的下降，外周内环境平衡机制变得越来越重要。事实上，胸腺功能的丧失不会导致T细胞数量的进行性下降，因为外周机制确保了由于残留细胞的增殖而保持T细胞群体的大小。然而，我们目前对“内环境平衡”或淋巴细胞减少诱导的增殖的基本机制的理解表明，这种维持种群规模的驱动力可能伴随着TCR多样性的丧失和自身反应性效应器T细胞的出现。这一预测得到了实验和临床证据的支持。这一考虑很重要，因为在临床实践中，淋巴细胞减少通常被视为病毒感染、癌症治疗、自身免疫和移植物排斥反应的结果。淋巴细胞减少可能是病毒感染和自身免疫之间的简单联系，也可能是目前临床上使用的非常有效但非特异的免疫抑制药物常见失败的原因之一。
It is well recognized that the composition of the mature T cell population is subject to strict homeostatic control. The TCR repertoire and relative proportions of various T cell subsets are established in the thymus, and continue to be shaped and regulated in the periphery. As the thymic function declines, peripheral homeostatic mechanisms assume increasing importance. Indeed, loss of thymic function does not lead to progressive decline of T cell numbers because peripheral mechanisms ensure that the size of the T cell population is maintained due to proliferation of residual cells. However, our current understanding of the basic mechanisms of ‘homeostatic’ or lymphopenia-induced proliferation suggests that this drive to maintain population size may be accompanied by loss of TCR diversity and emergence of auto-reactive effector T cells. This prediction is supported by experimental and clinical evidence. This consideration is important because lymphopenia is seen commonly in clinical practice as a consequence of viral infections, or medical treatment of cancer, autoimmunity, and graft rejection. Lymphopenia may be a simple link between viral infections and autoimmunity, and may be one reason for common failure of very potent, but non-specific, immunosuppressive drugs in current clinical use.
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DOI：
10.1084/jem.20021387
发表时间：
2003-02-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barthlott T;Kassiotis G;Stockinger B
通讯作者：
Stockinger B
DOI：
10.1073/pnas.89.21.10365
发表时间：
1992-11-01
影响因子：
11.1
作者：
GROSSMAN, Z;PAUL, WE
通讯作者：
PAUL, WE
影响因子：
168.9
作者：
Coles, AJ;Wing, N;Compston, A
通讯作者：
Compston, A
幼稚CD4+ T细胞的存活中，主要的组织相容性复合物分子是否参与？
DOI：
10.1084/jem.20030963
发表时间：
2003-10-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Grandjean I;Duban L;Bonney EA;Corcuff E;Di Santo JP;Matzinger P;Lantz O
通讯作者：
Lantz O
DOI：
10.1084/jem.192.4.549
发表时间：
2000-08-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cho BK;Rao VP;Ge Q;Eisen HN;Chen J
通讯作者：
Chen J