Deficits in generalized cognitive ability, visual sensorimotor function, and inhibitory control represent discrete domains of neurobehavioral deficit in psychotic disorders.
Deficits in generalized cognitive ability, visual sensorimotor function, and inhibitory control represent discrete domains of neurobehavioral deficit in psychotic disorders.
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DOI：
10.1016/j.schres.2021.07.036
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发表时间：
2021-10
影响因子：
4.5
通讯作者：
Hill SK
中科院分区：
文献类型：
--
作者：
Eskridge CLM;Hochberger WC;Kaseda ET;Lencer R;Reilly JL;Keedy SK;Keefe RSE;Pearlson GD;Keshavan MS;Tamminga CA;Sweeney JA;Hill SK
Psychotic disorders are characterized by impaired cognition, yet some reports indicate specific deficits extend beyond reduced general cognitive ability. This study utilized exploratory and confirmatory factor analytic methods to evaluate the latent structure of a broad neurocognitive battery used in the Bipolar-Schizophrenia Network of Intermediate Phenotypes (B-SNIP) study, which included neuropsychological and neurophysiological measures in psychotic disorder probands and their unaffected first-degree relatives. Findings indicate that the factor structure of data from this set of assessments is more complex than the unitary factor of global cognitive ability underlying the Brief Assessment of Cognition in Schizophrenia (BACS). In addition to assessing generalized cognitive ability, two other factors were identified: visual sensorimotor function and inhibitory behavioral control. This complex cognitive architecture, derived in controls, generalized to patients across the psychosis spectrum and to their unaffected relatives. These findings highlight the need for a more differentiated assessment of neurobehavioral functions in studies designed to test for diagnostically specific biomarkers, endophenotypes for gene discovery and beneficial effects of therapeutics on cognitive function.
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影响因子：
6.8
作者：
Lencer R;Mills LJ;Alliey-Rodriguez N;Shafee R;Lee AM;Reilly JL;Sprenger A;McDowell JE;McCarroll SA;Keshavan MS;Pearlson GD;Tamminga CA;Clementz BA;Gershon ES;Sweeney JA;Bishop JR
通讯作者：
Bishop JR
DOI：
10.1176/appi.ajp.2015.14091200
发表时间：
2016-04-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Clementz BA;Sweeney JA;Hamm JP;Ivleva EI;Ethridge LE;Pearlson GD;Keshavan MS;Tamminga CA
通讯作者：
Tamminga CA
影响因子：
4.5
作者：
Lencer R;Sprenger A;Reilly JL;McDowell JE;Rubin LH;Badner JA;Keshavan MS;Pearlson GD;Tamminga CA;Gershon ES;Clementz BA;Sweeney JA
通讯作者：
Sweeney JA
影响因子：
4.5
作者：
Nuechterlein, KH;Barch, DM;Heaton, RK
通讯作者：
Heaton, RK
影响因子：
10.6
作者：
Schretlen, David J.;Cascella, Nicola G.;Pearlson, Godfrey D.
通讯作者：
Pearlson, Godfrey D.