Double-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing.
Double-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing.
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DOI：
10.1016/j.neuron.2017.10.014
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发表时间：
2017-11-15
期刊：
影响因子：
16.2
通讯作者：
Trussell LO
中科院分区：
文献类型：
--
作者：
Irie T;Trussell LO
聚集成高频爆发的动作电位在神经计算中发挥着独特的作用。然而，人们对控制这些爆发的持续时间和概率的离子电流知之甚少。我们发现，在侧手翻抑制性中间神经元的耳蜗背核，爆发的可能性和他们的小穗之间的时间间隔控制的Ca 2+作用在两个nanodomains，质膜P/Q钙通道和内质网（ER）ryanodine受体和另一个ryanodine受体和大电导，电压和Ca 2+激活的K+（BK）通道之间。每一个穗触发钙2+诱导的钙释放（CICR）从ER体细胞，但不是轴突或树突，质膜下立即。此外，免疫标记表明兰尼碱受体和BK通道的密切并列。体细胞质膜和细胞膜下内质网通道之间的双纳米结构域偶联为在毫秒时间尺度上快速控制动作电位提供了独特的机制。
Action potentials clustered into high-frequency bursts play distinct roles in neural computations. However, little is known about ionic currents that control the duration and probability of these bursts. We found that, in cartwheel inhibitory interneurons of the dorsal cochlear nucleus, the likelihood of bursts and the interval between their spikelets were controlled by Ca2+ acting across two nanodomains, one between plasma membrane P/Q Ca2+ channels and endoplasmic reticulum (ER) ryanodine receptors and another between ryanodine receptors and large-conductance, voltage- and Ca2+-activated K+ (BK) channels. Each spike triggered Ca2+-induced Ca2+-release (CICR) from ER immediately beneath somatic, but not axonal or dendritic, plasma membrane. Moreover, immunolabeling demonstrated close apposition of ryanodine receptors and BK channels. Double nanodomain coupling between somatic plasma membrane and hypolemmal ER cisterns provides a unique mechanism for rapid control of action potentials on the millisecond time scale.
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影响因子：
16.2
作者：
Bender, Kevin J.;Ford, Christopher P.;Trussell, Laurence O.
通讯作者：
Trussell, Laurence O.
BK 通道对细胞兴奋性的影响取决于其亚细胞位置。
影响因子：
5.3
作者：
Bock T;Stuart GJ
通讯作者：
Stuart GJ
影响因子：
7.8
作者：
Henkart, M;Landis, D M;Reese, T S
通讯作者：
Reese, T S
DOI：
10.1523/jneurosci.2921-12.2013
发表时间：
2013-02-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Indriati DW;Kamasawa N;Matsui K;Meredith AL;Watanabe M;Shigemoto R
通讯作者：
Shigemoto R
影响因子：
2.5
作者：
Benton, Mark D.;Lewis, Amanda H.;Raman, Indira M.
通讯作者：
Raman, Indira M.