Same modulation but different starting points: performance modulates age differences in inferior frontal cortex activity during word-retrieval.
Same modulation but different starting points: performance modulates age differences in inferior frontal cortex activity during word-retrieval.
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DOI：
10.1371/journal.pone.0033631
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Crosson B
中科院分区：
文献类型：
--
作者：
Meinzer M;Flaisch T;Seeds L;Harnish S;Antonenko D;Witte V;Lindenberg R;Crosson B
在正常老化的单词检索缺陷的神经基础很少被评估，以前的几个功能成像研究发现，增强活动的右前额叶健康老年人相比，年轻的成年人。然而，更明显的右前额叶招聘主要是在具有挑战性的任务条件下观察。此外，任务难度的增加可能会导致年轻参与者双侧腹侧额下回（vIFG）的活动增强。因此，出现的问题是否增加活动在老年参与者代表一个年龄相关的现象或反映任务难度的影响。在本研究中，我们操纵任务难度在明显的语义和音素词的生成，并使用功能磁共振成像评估活动模式的vIFG在健康的年轻人和老年人（N = 16/组;平均年龄：24与69岁）。 在更困难的任务条件下，两组人都做出了更少的正确反应。总体而言，年龄较大的参与者产生的正确反应较少，并且在右侧vIFG中显示出更明显的任务相关活动。然而，在更困难的条件下，两组都发现活动增加。活动的绝对程度与各组、任务和难度水平的表现相关。活动调节（困难与容易的条件）与各组和任务的表现下降相关。总之，vIFG活性水平和活性调节在两组中以相似的方式由性能准确性介导。右vIFG活性的组间差异由性能准确性解释，这需要在未来的健康和病理老化的功能成像研究中加以考虑。
The neural basis of word-retrieval deficits in normal aging has rarely been assessed and the few previous functional imaging studies found enhanced activity in right prefrontal areas in healthy older compared to younger adults. However, more pronounced right prefrontal recruitment has primarily been observed during challenging task conditions. Moreover, increased task difficulty may result in enhanced activity in the ventral inferior frontal gyrus (vIFG) bilaterally in younger participants as well. Thus, the question arises whether increased activity in older participants represents an age-related phenomenon or reflects task difficulty effects. In the present study, we manipulated task difficulty during overt semantic and phonemic word-generation and used functional magnetic resonance imaging to assess activity patterns in the vIFG in healthy younger and older adults (N = 16/group; mean age: 24 vs. 69 years). Both groups produced fewer correct responses during the more difficult task conditions. Overall, older participants produced fewer correct responses and showed more pronounced task-related activity in the right vIFG. However, increased activity during the more difficult conditions was found in both groups. Absolute degree of activity was correlated with performance across groups, tasks and difficulty levels. Activity modulation (difficult vs. easy conditions) was correlated with the respective drop in performance across groups and tasks. In conclusion, vIFG activity levels and modulation of activity were mediated by performance accuracy in a similar way in both groups. Group differences in the right vIFG activity were explained by performance accuracy which needs to be considered in future functional imaging studies of healthy and pathological aging.
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影响因子：
2.5
作者：
Abel, Stefanie;Dressel, Katharina;Huber, Walter
通讯作者：
Huber, Walter
DOI：
10.1017/s135561770397010x
发表时间：
2003-11-01
影响因子：
2.6
作者：
Crosson, B;Benefield, H;Briggs, RW
通讯作者：
Briggs, RW
影响因子：
16.2
作者：
Gold, BT;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
4.3
作者：
Fling BW;Peltier SJ;Bo J;Welsh RC;Seidler RD
通讯作者：
Seidler RD
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF