Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates.
Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates.
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DOI：
10.1016/j.neuroimage.2013.01.035
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发表时间：
2014-01-15
期刊：
影响因子：
5.7
通讯作者：
Franceschini MA
中科院分区：
文献类型：
--
作者：
Roche-Labarbe N;Fenoglio A;Radhakrishnan H;Kocienski-Filip M;Carp SA;Dubb J;Boas DA;Grant PE;Franceschini MA
血流动力学功能反应在无数脑功能和认知研究中被用作神经元活动的可靠标记。然而，在新生儿和婴儿中，关于典型反应的文献中出现了相互矛盾的结果，并且关于脑代谢和功能激活的信息很少。所有血液动力学成分和氧代谢的测量是了解发育中的大脑神经血管耦合的关键。为此，我们结合多种近红外光谱技术，以测量氧合和脱氧血红蛋白浓度，脑血容量（CBV），和相对脑血流量（CBF）在体感皮层的6个早产儿在被动触觉刺激的手。通过结合这些措施，我们估计相对变化的脑代谢率的氧消耗（rCMRO 2）。CBF在刺激开始后立即开始增加，并在血容量之前恢复到基线。这与毛细血管前小动脉主动扩张驱动CBF反应的模型一致，随后CBV增加受毛细血管和静脉被动扩张以容纳额外血液的影响。使用稳态公式估计的rCMRO 2显示出双相模式：刺激开始后立即增加，随后由于血流比氧合更快地返回基线而导致刺激后下冲。然而，由于早产儿的血管系统不成熟，假设从动脉到静脉室的平均通过时间较长，可减少刺激后下冲，并将流量/消耗比增加至更接近文献中报告的成人值。我们首次报道了早产儿功能激活过程中局部rCBF和rCMRO 2的变化。除了血红蛋白浓度变化之外，测量这些变量的能力对于理解发育中大脑中的神经血管耦合以及将这种耦合用作新生儿中可靠的功能成像标记物至关重要。
The hemodynamic functional response is used as a reliable marker of neuronal activity in countless studies of brain function and cognition. In newborns and infants, however, conflicting results have appeared in the literature concerning the typical response, and there is little information on brain metabolism and functional activation. Measurement of all hemodynamic components and oxygen metabolism is critical for understanding neurovascular coupling in the developing brain. To this end, we combined multiple near infrared spectroscopy techniques to measure oxy- and deoxy-hemoglobin concentrations, cerebral blood volume (CBV), and relative cerebral blood flow (CBF) in the somatosensory cortex of 6 preterm neonates during passive tactile stimulation of the hand. By combining these measures we estimated relative changes in the cerebral metabolic rate of oxygen consumption (rCMRO2). CBF starts increasing immediately after stimulus onset, and returns to baseline before blood volume. This is consistent with the model of pre-capillary arteriole active dilation driving the CBF response, with a subsequent CBV increase influenced by capillaries and veins dilating passively to accommodate the extra blood. rCMRO2 estimated using the steady-state formulation shows a biphasic pattern: an increase immediately after stimulus onset, followed by a post-stimulus undershoot due to blood flow returning faster to baseline than oxygenation. However, assuming a longer mean transit time from the arterial to the venous compartment, due to the immature vascular system of premature infants, reduces the post-stimulus undershoot and increases the flow/consumption ratio to values closer to adult values reported in the literature. We are the first to report changes in local rCBF and rCMRO2 during functional activation in preterm infants. The ability to measure these variables in addition to hemoglobin concentration changes is critical for understanding neurovascular coupling in the developing brain, and for using this coupling as a reliable functional imaging marker in neonates.
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影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
DOI：
10.3389/fnene.2010.00008
发表时间：
2010
期刊：
Frontiers in neuroenergetics
影响因子：
--
作者：
Buxton RB
通讯作者：
Buxton RB
影响因子：
2.9
作者：
Blockley, Nicholas P.;Griffeth, Valerie E. M.;Simon, Aaron B.;Buxton, Richard B.
通讯作者：
Buxton, Richard B.
影响因子：
3.6
作者：
Franceschini, Maria Angela;Thaker, Sonal;Grant, P. Ellen
通讯作者：
Grant, P. Ellen
影响因子：
5.7
作者：
Hoge, RD;Franceschini, MA;Boas, DA
通讯作者：
Boas, DA