Typical Fluorescent Sensors Exploiting Molecularly Imprinted Hydrogels for Environmentally and Medicinally Important Analytes Detection.
Typical Fluorescent Sensors Exploiting Molecularly Imprinted Hydrogels for Environmentally and Medicinally Important Analytes Detection.
复制标题
利用分子印迹水凝胶进行环境和医学重要分析物检测的典型荧光传感器
DOI：
10.3390/gels7020067
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发表时间：
2021-06-08
期刊：
影响因子：
--
通讯作者：
Pan G
中科院分区：
文献类型：
--
作者：
Zou L;Ding R;Li X;Miao H;Xu J;Pan G
本工作利用分子印迹聚合物水凝胶（MIPG）的自荧光特性和受体荧光效应，分别构建了两种典型的玉米赤霉烯酮（ZON）和葡萄糖醛酸（GA）荧光传感器。尽管在MIPG荧光传感器上已经取得了显著的进展，其被赋予了优于天然受体传感器的稳定性，但是在商业化方面，对开发具有成本效益、易于使用、便携式优点的传感装置的需求越来越大。放大MIPG-荧光传感器的商业潜力，MIPG_ZON是以玉米赤霉酮（ZON的类似物）为模板合成的，即使在玉米样品中也表现出良好的检测性能，检测限为1.6 μM。与此同时，荧光素掺入的MIPG_GA被获得并直接用于癌细胞成像，具有显著的特异性和选择性。最后但并非最不重要的是，我们的综合应用结果为MIPG荧光传感器提供了新的机会，用于环境和医学重要分析物的检测。
In this work, two typical fluorescent sensors were generated by exploiting molecularly imprinted polymeric hydrogels (MIPGs) for zearalenone (ZON) and glucuronic acid (GA) detection, via the analyte’s self-fluorescence property and receptor’s fluorescence effect, respectively. Though significant advances have been achieved on MIPG-fluorescent sensors endowed with superior stability over natural receptor-sensors, there is an increasing demand for developing sensing devices with cost-effective, easy-to-use, portable advantages in terms of commercialization. Zooming in on the commercial potential of MIPG-fluorescent sensors, the MIPG_ZON is synthesized using zearalanone (an analogue of ZON) as template, which exhibits good detection performance even in corn samples with a limit of detection of 1.6 μM. In parallel, fluorescein-incorporated MIPG_GA is obtained and directly used for cancer cell imaging, with significant specificity and selectivity. Last but not least, our consolidated application results unfold new opportunities for MIPG-fluorescent sensors for environmentally and medicinally important analytes detection.
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