The PRINTS database: a fine-grained protein sequence annotation and analysis resource--its status in 2012.

The PRINTS database: a fine-grained protein sequence annotation and analysis resource--its status in 2012.
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DOI:
10.1093/database/bas019
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发表时间:
2012
期刊:
Database : the journal of biological databases and curation
影响因子:
--
通讯作者:
Mitchell AL
Mitchell AL
中科院分区:
其他
文献类型:
--
作者:
Attwood TK;Coletta A;Muirhead G;Pavlopoulou A;Philippou PB;Popov I;Romá-Mateo C;Theodosiou A;Mitchell AL

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PRINTS数据库现已进入第21个年头,其中包含诊断蛋白质家族“指纹”的集合。指纹是一组保守的基序,在多个序列比对中很明显,其独特的相互关系为特定的蛋白质家族和结构/功能域提供了独特的签名。因此,它们可用于将未表征的序列分配给已知的家族,并因此推断暂定的功能、结构和/或进化关系。2012年2月发布(version 42.0)包括2156个指纹,编码12444个独立的模体,涵盖了一系列的球状和膜蛋白,模块多肽等。并介绍了一些最新的发展,这些发展有助于使我们的各种注释和分析工具更易于使用,广泛可用。数据库URL:www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/
The PRINTS database, now in its 21st year, houses a collection of diagnostic protein family ‘fingerprints’. Fingerprints are groups of conserved motifs, evident in multiple sequence alignments, whose unique inter-relationships provide distinctive signatures for particular protein families and structural/functional domains. As such, they may be used to assign uncharacterized sequences to known families, and hence to infer tentative functional, structural and/or evolutionary relationships. The February 2012 release (version 42.0) includes 2156 fingerprints, encoding 12 444 individual motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. Here, we report the current status of the database, and introduce a number of recent developments that help both to render a variety of our annotation and analysis tools easier to use and to make them more widely available. Database URL: www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/
DOI: 10.1093/nar/19.suppl.2241
发表时间: 1991-04-25
影响因子: 14.9
作者:
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通讯作者: BAIROCH, A
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发表时间: 2008-01-01
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DOI: 10.1093/nar/gkr981
发表时间: 2012-01
影响因子: 14.9
作者:
UniProt Consortium
通讯作者: UniProt Consortium