Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women.
Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women.
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DOI：
10.3390/pharmacy9020071
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发表时间：
2021-03-27
期刊：
影响因子：
--
通讯作者：
Hutcherson TC
中科院分区：
文献类型：
--
作者：
Cieri-Hutcherson NE;Jaenecke A;Bahia A;Lucas D;Oluloro A;Stimmel L;Hutcherson TC
本系统综述评估了l-精氨酸单独或联合治疗女性性欲减退症（HSDD）或相关疾病（如女性性兴趣/觉醒障碍和女性性觉醒障碍）的疗效和安全性。使用关键词“精氨酸”、“Lady Prelox”、“ArginMax”、“Stronvivo”、“Ristela”、“性欲减退”、“女性性兴趣唤起障碍”、“女性性唤起障碍”、“性功能障碍”、“性行为”、“性交困难”、“libido”及其排列进行检索。如果是主要文献，对HSDD或相关疾病的女性进行研究，并以英文全文出版，则保留相关记录。5项随机对照试验和2项非随机研究符合入选标准。七项研究中有六项报告称，女性性功能指数的总平均得分有所提高，或者在多个领域都有显著提高。一项评估阴道脉冲幅度的研究发现，与安慰剂相比，联合治疗组的阴道脉冲幅度有统计学上的显著增加。没有明显的副作用报告。根据Cochrane评估，7项研究中有4项存在潜在的偏倚风险。本系统综述发现，无论年龄大小，含有l-精氨酸的ArginMax或Lady Prelox组合产品均可用于治疗HSDD及相关疾病。
This systematic review evaluates the efficacy and safety of l-arginine alone or in combination for the treatment of women with hypoactive sexual desire disorder (HSDD) or related conditions, such as female sexual interest/arousal disorder and female sexual arousal disorder. Medline, Embase, International Pharmaceutical Abstracts, Science Direct, and the Cumulative Index to Nursing and Allied Health Literature were searched using keywords “arginine”, “Lady Prelox”, “ArginMax”, “Stronvivo”, “Ristela”, “hypoactive sexual desire disorder”, “female sexual interest arousal disorder”, “female sexual arousal disorder”, “sexual dysfunction”, “sexual behavior”, “dyspareunia”, “libido”, and permutations thereof. Relevant records were retained if they were primary literature, conducted in women with HSDD or related conditions, and published as full text in English. Five randomized controlled trials and two nonrandomized studies met eligibility criteria. Six of the seven studies reported either an increase in the total mean Female Sexual Function Index score or significant increases in multiple domains therein. One study assessed vaginal pulse amplitude and found a statistically significant increase in a combination treatment group compared to placebo. No significant side effects were reported. Four of seven studies had potential risk-of-bias concerns per Cochrane assessments. This systematic review found that combination products containing l-arginine in the form of ArginMax or Lady Prelox may be considered for the treatment of HSDD and related conditions in women regardless of age.
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