Sensitivity to ethanol and other hedonic stimuli in an animal model of adolescence: implications for prevention science?
Sensitivity to ethanol and other hedonic stimuli in an animal model of adolescence: implications for prevention science?
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DOI：
10.1002/dev.20457
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发表时间：
2010-04
影响因子：
2.2
通讯作者：
Varlinskaya, Elena I.
中科院分区：
文献类型：
--
作者：
Spear, Linda Patia;Varlinskaya, Elena I.
关键词：
与年龄相关的对食欲和厌恶刺激的敏感性模式似乎有着深刻的进化根源，在青春期，在一些相对古老的大脑系统中可以看到明显的发育转变，这些系统对激励和指导奖励相关行为至关重要。使用一个简单的老鼠青春期动物模型，青少年对酒精、其他药物和某些自然刺激的积极奖励效果比成年人更敏感，而对这些刺激的厌恶特性不那么敏感。青少年典型的酒精敏感性可能因先前的压力或酒精接触史以及遗传脆弱性而进一步加剧，从而导致青少年酒精使用水平相对较高，并且可能增加出现滥用障碍的可能性。考虑到这些基础研究结果对预防科学的一些潜在（尽管是暂时的）影响。
Age-related patterns of sensitivity to appetitive and aversive stimuli seemingly have deep evolutionary roots, with marked developmental transformations seen during adolescence in a number of relatively ancient brain systems critical for motivating and directing reward-related behaviors. Using a simple animal model of adolescence in the rat, adolescents have been shown to be more sensitive than their adult counterparts to positive rewarding effects of alcohol, other drugs, and certain natural stimuli, while being less sensitive to the aversive properties of such stimuli. Adolescent-typical alcohol sensitivities may be exacerbated further by a history of prior stress or alcohol exposure as well as by genetic vulnerabilities, permitting relatively high levels of adolescent alcohol use and perhaps an increased probability for the emergence of abuse disorders. A number of potential (albeit tentative) implications of these basic research findings for prevention science are considered.
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DOI：
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发表时间：
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影响因子：
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影响因子：
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