Acupuncture on Obesity: Clinical Evidence and Possible Neuroendocrine Mechanisms.
Acupuncture on Obesity: Clinical Evidence and Possible Neuroendocrine Mechanisms.
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DOI：
10.1155/2018/6409389
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Zhang K;Zhou S;Wang C;Xu H;Zhang L
针灸作为一种补充和替代药物，是控制肥胖的有效治疗选择。本文对针灸治疗肥胖症的疗效进行了Meta分析，并对针灸治疗肥胖症的作用机制进行了综述。 我们检索了从开始到2017年4月的6个数据库，无语言限制。符合条件的研究包括针灸与比较对照（（1）假针灸，（2）无治疗，（3）饮食和运动，（4）常规药物）。主要结局包括BMI、体重减轻和心血管事件（CVD）的发生率。次要结局包括腰围（WC）、腰臀比（WHR）、体脂质量百分比、体脂质量（kg）、总胆固醇（TC）、甘油三酯（TG）、血糖、低密度脂蛋白胆固醇（LDL-c）降低、高密度脂蛋白胆固醇（HDL-c）升高和不良反应。采用科克伦偏倚风险工具评价随机对照试验的质量。根据针刺类型进行亚组分析。使用随机效应模型调整纳入研究的异质性。使用漏斗图评估发表偏倚。 我们纳入了21项研究，1389名受试者。与假针灸相比，（MD=-1.22，95% CI=-1.87至-0.56），体重（MD=-1.54，95%CI =-2.98至-0.11），体脂量（kg）（MD=-1.31，95%CI =-2.47至-0.16）和TC（SMD=-0.63，95%CI =-1.00至-0.25）。与未治疗组相比，（MD=-1.92，95% CI=-3.04至-0.79），WHR（MD=-0.05，95% CI=-0.09至-0.02），TC（MD=-0.26，95% CI=-0.48至-0.03）和TG（MD=-0.2995%CI =-0.39 ~-0.18），与节食加运动组相比，（MD=-1.24，95%CI =-1.87 ~-0.62）和体重（MD=-3.27，95%CI =-5.07 ~-1.47）。 我们的结论是，针灸是一种有效的治疗肥胖症，并推断可能涉及神经内分泌调节。
Acupuncture, as one of the complementary and alternative medicines, represents an efficient therapeutic option for obesity control. We conducted a meta-analysis to investigate the effectiveness of acupuncture in obesity and also summarized the available studies on exploring the mechanisms. We searched six databases from the inception to April 2017 without language restriction. Eligible studies consisted of acupuncture with comparative controls ((1) sham acupuncture, (2) no treatment, (3) diet and exercise, and (4) conventional medicine). The primary outcomes consisted of BMI, body weight reduction, and incidence of cardiovascular events (CVD). Secondary outcomes included waist circumference (WC), waist-to-hip ratio (WHR), body fat mass percent, body fat mass (kg), total cholesterol (TC), triglyceride (TG), glucose, low density lipoprotein cholesterol (LDL-c) reduction, high density lipoprotein cholesterol (HDL-c) increase, and adverse effects. The quality of RCTs was assessed by the Cochrane Risk of Bias Tool. Subgroup analyses were performed according to types of acupuncture. A random effects model was used to adjust for the heterogeneity of the included studies. Publication bias was assessed using funnel plots. We included 21 studies with 1389 participants. When compared with sham acupuncture, significant reductions in BMI (MD=-1.22, 95%CI=-1.87 to -0.56), weight (MD=-1.54, 95%CI=-2.98 to -0.11), body fat mass (kg) (MD=-1.31, 95%CI=-2.47 to -0.16), and TC (SMD=-0.63, 95%CI=-1.00 to -0.25) were found. When compared with no treatment group, significant reductions of BMI (MD=-1.92, 95%CI=-3.04 to -0.79), WHR (MD=-0.05, 95%CI=-0.09 to -0.02), TC (MD=-0.26, 95%CI=-0.48 to -0.03), and TG (MD=-0.29 95%CI=-0.39 to -0.18) were found. When compared with diet and exercise group, significant reduction in BMI (MD=-1.24, 95%CI=-1.87 to -0.62) and weight (MD=-3.27 95%CI=-5.07 to -1.47) was found. Adverse effects were reported in 5 studies. We concluded that acupuncture is an effective treatment for obesity and inferred that neuroendocrine regulation might be involved.
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