The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson's Disease.
The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson's Disease.
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DOI：
10.3389/fneur.2013.00134
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发表时间：
2013
影响因子：
3.4
通讯作者：
Jakowec MW
中科院分区：
文献类型：
--
作者：
Beeler JA;Petzinger G;Jakowec MW
帕金森病的运动功能障碍被认为主要是由进行性多巴胺去神经支配期间背侧纹状体及其相关的皮质纹状体和丘脑纹状体回路的病理生理学引起的。这些回路的一个功能是提供一个过滤器，选择性地促进或抑制皮层活动，以优化皮层处理，使运动反应迅速而有效。皮质纹状体突触可塑性介导的学习，这种性能优化过滤器的基础。在多巴胺去神经支配下，皮质纹状体可塑性改变，导致异常学习，诱导不适当的基底神经节过滤，阻碍而不是优化皮层处理。人类成像表明，皮质活动的增加可能会补偿PD患者的纹状体功能障碍。在这篇透视文章中，我们考虑了皮质纹状体突触的异常学习如何损害皮质的处理和学习，并破坏潜在的皮质代偿机制。阻断或纠正异常的皮质纹状体可塑性可以保护皮质功能，并支持皮质代偿机制，减轻与进行性多巴胺去神经支配相关的功能下降。
Motor dysfunction in Parkinson’s disease is believed to arise primarily from pathophysiology in the dorsal striatum and its related corticostriatal and thalamostriatal circuits during progressive dopamine denervation. One function of these circuits is to provide a filter that selectively facilitates or inhibits cortical activity to optimize cortical processing, making motor responses rapid and efficient. Corticostriatal synaptic plasticity mediates the learning that underlies this performance-optimizing filter. Under dopamine denervation, corticostriatal plasticity is altered, resulting in aberrant learning that induces inappropriate basal ganglia filtering that impedes rather than optimizes cortical processing. Human imaging suggests that increased cortical activity may compensate for striatal dysfunction in PD patients. In this Perspective article, we consider how aberrant learning at corticostriatal synapses may impair cortical processing and learning and undermine potential cortical compensatory mechanisms. Blocking or remediating aberrant corticostriatal plasticity may protect cortical function and support cortical compensatory mechanisms mitigating the functional decline associated with progressive dopamine denervation.
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影响因子：
11.2
作者：
Beeler, Jeff A.;Cao, Zhen Fang Huang;Kheirbek, Mazen A.;Ding, Yunmin;Koranda, Jessica;Murakami, Mari;Kang, Un Jung;Zhuang, Xiaoxi
通讯作者：
Zhuang, Xiaoxi
影响因子：
8.8
作者：
Beeler JA;Frank MJ;McDaid J;Alexander E;Turkson S;Bernardez Sarria MS;McGehee DS;Zhuang X
通讯作者：
Zhuang X
DOI：
10.1073/pnas.0502762102
发表时间：
2005-08-30
影响因子：
11.1
作者：
Lehéricy, S;Benali, H;Doyon, J
通讯作者：
Doyon, J
影响因子：
14.5
作者：
Catalan, MJ;Ishii, K;Hallett, M
通讯作者：
Hallett, M
影响因子：
15.9
作者：
CHEVALIER, G;DENIAU, JM
通讯作者：
DENIAU, JM