Hidden 'pit'falls in deciphering the gonadotropin releasing hormone neuroendocrine cell lineage.

Hidden 'pit'falls in deciphering the gonadotropin releasing hormone neuroendocrine cell lineage.
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DOI:
10.1111/jne.13039
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发表时间:
2021-11
影响因子:
3.2
通讯作者:
Wray S
Wray S
中科院分区:
医学3区
文献类型:
--
作者:
Shan Y;Wray S

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To this day, the identity of GnRH progenitors remains unclear. However, the visualization of different developmental markers in subsets of GnRH neurons during early embryonic stages raised the possibility of at least two GnRH subpopulations. This observation led directly to a second question. Does visualization of different developmental markers in subsets of GnRH neurons reflect functional heterogeneity? This question remains unanswered, but as we learn more about the GnRH system, functional GnRH subpopulations becomes critically important to understanding GnRH function. This review addresses the development of the neuroendocrine GnRH system, specifically the heterogeneity of the GnRH neuroendocrine population.
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