A novel recombinant lineage's contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012-2013.
A novel recombinant lineage's contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012-2013.
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DOI：
10.1038/srep11700
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发表时间：
2015-06-30
影响因子：
4.6
通讯作者：
Yao Z
中科院分区：
文献类型：
--
作者：
Feng X;Guan W;Guo Y;Yu H;Zhang X;Cheng R;Wang Z;Zhang Z;Zhang J;Li H;Zhuang Y;Zhang H;Lu Z;Li M;Yu H;Bao Y;Hu Y;Yao Z
自2012年底以来，柯萨奇病毒A6（CVA 6）已逐渐成为中国多个省份手足口病（HFMD）的主要病原体。2012年1月至2013年9月，中国上海市共626例确诊为手足口病的患者入组本研究。其中，对292例CVA 6感染病例进行了临床分析。还进行了全基因组测序、重组和系统发育分析。在2012年11月中国上海爆发的CVA 6相关HFMD期间发现了重组CVA 6单系谱系，占研究期间CVA 6菌株的21.9%（64/292）。分离分析表明，CVA 6病毒的2C基因可能来源于人群中流行的柯萨奇病毒A4（CVA 4）株。临床观察表明，这种重组CVA 6病毒比非重组CVA 6病毒导致更广泛的皮疹。这种新出现的CVA 6谱系与2012年至2013年上海相当比例的手足口病病例相关，并对公共卫生构成潜在威胁。
Since late 2012, coxsackievirus A6 (CVA6) has gradually become the predominant pathogen responsible for hand-foot-mouth disease (HFMD) in several provinces of China. A total of 626 patients diagnosed with HFMD in Shanghai, China from January 2012 to September 2013 were enrolled in this study. Of these, 292 CVA6 infected cases were subjected to clinical analyses. Whole-genome sequencing, recombination and phylogenetic analyses were also performed. A recombinant CVA6 monophyletic lineage was found during an outbreak of CVA6-associated HFMDs in Shanghai, China in November 2012, and accounted for 21.9% (64/292) of the CVA6 strains during the study period. Recombination analyses showed that the 2C gene of the novel CVA6 virus was probably derived from a coxsackievirus A4 (CVA4) strain circulating in the population. Clinical observation showed that this recombinant CVA6 virus led to a more generalized rash than did the non-recombinant CVA6 virus. This newly emerged CVA6 lineage was associated with a considerable proportion of HFMD cases from 2012 to 2013 in Shanghai, and poses a potential threat to public health.
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