Reversible switching between epigenetic states in honeybee behavioral subcastes.
Reversible switching between epigenetic states in honeybee behavioral subcastes.
复制标题
在蜜蜂行为子播种中的表观遗传状态之间可逆切换。
DOI:
10.1038/nn.3218
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发表时间:
2012-10
影响因子:
25
通讯作者:
Feinberg, Andrew P.
中科院分区:
文献类型:
--
作者:
Herb, Brian R.;Wolschin, Florian;Hansen, Kasper D.;Aryee, Martin J.;Langmead, Ben;Irizarry, Rafael;Amdam, Gro V.;Feinberg, Andrew P.
In honeybee societies, distinct caste phenotypes are created from the same genotype, suggesting a role for epigenetics in deriving these behaviorally different phenotypes. We found no differences in DNA methylation between irreversible worker/queen castes, but substantial differences between nurses and forager subcastes. Reverting foragers back to nurses reestablished methylation levels for a majority of genes and provided the first evidence in any organism of reversible epigenetic changes associated with behavior.
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