In vivo confocal microscopic observations of eyes diagnosed with posterior corneal vesicles
In vivo confocal microscopic observations of eyes diagnosed with posterior corneal vesicles
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诊断患有后角膜囊泡的眼睛的体内共焦显微镜观察
DOI：
10.1007/s10384-016-0473-x
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Hayashi Y
中科院分区：
文献类型：
--
作者：
Shiraishi A;Zheng X;Sakane Y;Hara Y;Hayashi Y
目的探讨活体共聚焦显微镜(IVCM)检测角膜后囊泡(PCV)的角膜形态特征。此外，比较PCV和后部多形性角膜营养不良(PPCD)患者的角膜形态特征。方法对经裂隙灯检查确诊为PCV的3男3女，年龄17~75岁。评估裂隙灯检查结果、镜面显微镜图像、角膜内皮细胞密度(CDS)、中央角膜厚度和IVCM图像。结果6例PCV患者均有单侧后弹力膜及角膜内皮损害。裂隙灯生物显微镜检查显示5例PCV有宽阔的带状病变，1例PCV有多个水泡状病变。6例患者的IVCM图像与正常角膜内皮细胞一样，病变区域的角膜内皮细胞表现为等反射核和低反射细胞膜。患眼的CDS大约是非患眼的一半。PPCD患者的角膜IVCM图像显示出具有上皮细胞特征的多形性细胞，具有高反光的核。这些发现表明PCV是一个不同于PPCD的独特的临床实体。
PurposeTo determine the morphological characteristics of the cornea in eyes with posterior corneal vesicles (PCV) determined by in vivo confocal microscopy (IVCM). In addition, to compare the morphological characteristics of the corneas of eyes with PCV to those of eyes with posterior polymorphous corneal dystrophy (PPCD).MethodsThree males and three females aged 17–75 years who were diagnosed with PCV by slit-lamp biomicroscopic findings were studied. The slit-lamp findings, specular microscopic images, corneal endothelial cell densities (CDs), central corneal thickness, and IVCM images were evaluated. Three cases that had been diagnosed with PPCD were also evaluated, and the findings were compared to those in eyes with PCV.ResultsAll six cases of PCV had unilateral lesions of Descemet’s membrane and the corneal endothelium. Slit-lamp biomicroscopy showed broad, band-shaped lesions in five cases and multiple vesicle lesions in one case of PCV. The IVCM images of the six cases had a common appearance of the corneal endothelial cells in the affected areas showing iso-reflective nuclei and low reflective cell membranes as seen in normal corneal endothelial cells. The CDs in the affected eyes were about one-half of those of the not affected eyes. The IVCM images of the corneas of patients with PPCD showed polymorphic cells with hyperreflective nuclei, which are characteristics of epithelial cells.ConclusionsThe IVCM images demonstrated that the corneal endothelial cells of patients with PCV have normal morphology. These findings indicate that PCV is a distinct clinical entity different from PPCD.
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线性内皮囊泡或角膜后疱疹。
DOI：
10.1016/0002-9394(65)93748-7
发表时间：
1965
期刊：
American journal of ophthalmology-glaucoma
影响因子：
--
作者：
G. Kiffney
通讯作者：
G. Kiffney
遗传性角膜深层营养不良（多形性）。
DOI：
--
发表时间：
1969
期刊：
American journal of ophthalmology-glaucoma
影响因子：
--
作者：
M. Hogan;G. Bietti
通讯作者：
G. Bietti
后部多形性内皮营养不良的临床镜面显微镜。
DOI：
--
发表时间：
1983
期刊：
American journal of ophthalmology-glaucoma
影响因子：
--
作者：
Lawrence W. Hirst;G. O. Waring
通讯作者：
G. O. Waring
影响因子：
4.2
作者：
BORUCHOFF, SA;KUWABARA, T
通讯作者：
KUWABARA, T
角膜后部多形性营养不良
DOI：
--
发表时间：
2005
期刊：
Graefe's Archive for Clinical and Experimental Ophthalmology
影响因子：
--
作者：
G. P. Felice;P. Braidotti;G. Viale;F. Bergamini;P. Vinciguerra
通讯作者：
P. Vinciguerra