Connexin 43: A Target for the Treatment of Inflammation in Secondary Complications of the Kidney and Eye in Diabetes.
Connexin 43: A Target for the Treatment of Inflammation in Secondary Complications of the Kidney and Eye in Diabetes.
复制标题
连接蛋白43：糖尿病肾脏和眼部继发性并发症炎症治疗的靶点。
DOI：
10.3390/ijms23020600
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发表时间：
2022-01-06
影响因子：
5.6
通讯作者：
Hills CE
中科院分区：
文献类型：
--
作者：
Cliff CL;Williams BM;Chadjichristos CE;Mouritzen U;Squires PE;Hills CE
随着患病率的增加，糖尿病的特征是血糖升高和慢性炎症，这些炎症先于多种继发性并发症的发作，包括肾脏和眼睛的并发症。作为终末期肾病和工作人群失明的主要原因，比以往任何时候都更需要开发可以延迟和预防疾病进展的临床干预措施。连接蛋白是膜结合蛋白，其可以在细胞膜中形成孔（半通道）。在细胞应激和损伤的门控下，它们在病理生理条件下打开，并在此过程中释放“危险信号”，包括三磷酸腺苷进入细胞外环境。通过激活类β受体蛋白3炎性体与无菌性炎症相关，靶向异常半通道活性和释放这些危险信号，在多种疾病模型（包括糖尿病继发性并发症）中取得了良好的结果。在这篇综述中，我们提供了一个全面的更新，这些研究记录了异常连接蛋白半通道活性在糖尿病性眼病和肾病的发病机制中的作用，提前评估阻断这些靶组织中连接蛋白-43特异性半通道对组织健康和功能的疗效。
Of increasing prevalence, diabetes is characterised by elevated blood glucose and chronic inflammation that precedes the onset of multiple secondary complications, including those of the kidney and the eye. As the leading cause of end stage renal disease and blindness in the working population, more than ever is there a demand to develop clinical interventions which can both delay and prevent disease progression. Connexins are membrane bound proteins that can form pores (hemichannels) in the cell membrane. Gated by cellular stress and injury, they open under pathophysiological conditions and in doing so release ‘danger signals’ including adenosine triphosphate into the extracellular environment. Linked to sterile inflammation via activation of the nod-like receptor protein 3 inflammasome, targeting aberrant hemichannel activity and the release of these danger signals has met with favourable outcomes in multiple models of disease, including secondary complications of diabetes. In this review, we provide a comprehensive update on those studies which document a role for aberrant connexin hemichannel activity in the pathogenesis of both diabetic eye and kidney disease, ahead of evaluating the efficacy of blocking connexin-43 specific hemichannels in these target tissues on tissue health and function.
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影响因子：
--
作者：
Evans, W. Howard;Leybaert, Luc
通讯作者：
Leybaert, Luc
影响因子：
3.5
作者：
Burnstock G;Knight GE
通讯作者：
Knight GE
影响因子：
4.9
作者：
Bao YW;Yuan Y;Chen JH;Lin WQ
通讯作者：
Lin WQ
DOI：
10.3390/molecules25235533
发表时间：
2020-11-25
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
El-Sharkawy LY;Brough D;Freeman S
通讯作者：
Freeman S
DOI：
10.4321/s1889-836x2020000400008
发表时间：
2020-12-01
影响因子：
0.6
作者：
Carpintero-Fernández, P;Sánchez Temparno, A;Mayan, MD
通讯作者：
Mayan, MD