Biobehavioral Implications of Covid-19 for Transplantation and Cellular Therapy Recipients.
Biobehavioral Implications of Covid-19 for Transplantation and Cellular Therapy Recipients.
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DOI：
10.3389/fimmu.2022.877558
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
越来越多的文献强调了生物行为过程的重要性-定义为行为，心理，社会环境因素和生物过程的相互作用-移植和细胞治疗（TCT）患者的临床结果。TCT接受者特别容易受到与大流行状况相关的痛苦，并且代表了一个明显免疫功能低下的群体，其SARS-CoV-2感染的风险更大，结果更差。TCT患者的免疫和心理脆弱性的总和使他们特别容易受到与新冠肺炎大流行相关的不良生物行为后遗症的影响。应激和不良心理社会因素通过交感神经系统和下丘脑-垂体-肾上腺轴信号传导改变神经和内分泌通路，最终影响免疫细胞中的基因调节。反过来，与TCT相关的全身炎症和免疫失调导致神经内分泌和中枢神经系统功能失调，导致抑郁、疲劳、睡眠障碍和认知功能障碍的症状特征。在这篇文章中，我们借鉴了免疫学、心理学、神经科学、血液学和肿瘤学、Covid-19病理生理学以及TCT过程的文献，讨论它们如何相互交叉影响TCT结果，目的是概述生物行为因素在理解Covid-19和TCT之间的关系方面的重要性，现在和未来。我们讨论了抑郁，焦虑，疲劳，睡眠，社交孤立和孤独，神经认知障碍的作用，以及对感兴趣的亚群，包括儿科，护理人员和TCT捐赠者的具体影响。最后，我们讨论了可能优化受COVID-19影响的生物行为结果的保护性心理过程。
A growing body of literature has emphasized the importance of biobehavioral processes – defined as the interaction of behavior, psychology, socioenvironmental factors, and biological processes – for clinical outcomes among transplantation and cellular therapy (TCT) patients. TCT recipients are especially vulnerable to distress associated with pandemic conditions and represent a notably immunocompromised group at greater risk for SARS-CoV-2 infection with substantially worse outcomes. The summation of both the immunologic and psychologic vulnerability of TCT patients renders them particularly susceptible to adverse biobehavioral sequelae associated with the Covid-19 pandemic. Stress and adverse psychosocial factors alter neural and endocrine pathways through sympathetic nervous system and hypothalamic-pituitary-adrenal axis signaling that ultimately affect gene regulation in immune cells. Reciprocally, global inflammation and immune dysregulation related to TCT contribute to dysregulation of neuroendocrine and central nervous system function, resulting in the symptom profile of depression, fatigue, sleep disturbance, and cognitive dysfunction. In this article, we draw upon literature on immunology, psychology, neuroscience, hematology and oncology, Covid-19 pathophysiology, and TCT processes to discuss how they may intersect to influence TCT outcomes, with the goal of providing an overview of the significance of biobehavioral factors in understanding the relationship between Covid-19 and TCT, now and for the future. We discuss the roles of depression, anxiety, fatigue, sleep, social isolation and loneliness, and neurocognitive impairment, as well as specific implications for sub-populations of interest, including pediatrics, caregivers, and TCT donors. Finally, we address protective psychological processes that may optimize biobehavioral outcomes affected by Covid-19.
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影响因子：
3.7
作者：
Beattie S;Lebel S;Tay J
通讯作者：
Tay J
影响因子：
4.4
作者：
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通讯作者：
Cole SW
DOI：
10.1016/j.bbi.2013.08.012
发表时间：
2014-02
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Laudenslager ML
通讯作者：
Laudenslager ML
影响因子：
3.9
作者：
Carver, CS
通讯作者：
Carver, CS
DOI：
10.3109/10253890.2016.1146670
发表时间：
2016
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Bevans MF;Ross A;Wehrlen L;Klagholz SD;Yang L;Childs R;Flynn SL;Remaley AT;Krumlauf M;Reger RN;Wallen GR;Shamburek R;Pacak K
通讯作者：
Pacak K