Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND.
Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND.
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DOI：
10.2337/dc14-1231
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发表时间：
2015-02
期刊：
影响因子：
16.2
通讯作者：
Freedman BI
中科院分区：
文献类型：
--
作者：
Sink KM;Divers J;Whitlow CT;Palmer ND;Smith SC;Xu J;Hugenschmidt CE;Wagner BC;Williamson JD;Bowden DW;Maldjian JA;Freedman BI
Albuminuria and reduced kidney function are associated with cognitive impairment. Relationships between nephropathy and cerebral structural changes remain poorly defined, particularly in African Americans (AAs), a population at higher risk for both cognitive impairment and diabetes than European Americans. We examined the relationship between urine albumin:creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and cerebral MRI volumes in 263 AAs with type 2 diabetes. Cross-sectional associations between renal parameters and white matter (WM), gray matter (GM), hippocampal, and WM lesion (WML) volumes were assessed using generalized linear models adjusted for age, education, sex, BMI, hemoglobin A1c (HbA1c) level, and hypertension. Participants had a mean (SD) age of 60.2 years (9.7 years), and 62.7% were female. Mean diabetes duration was 14.3 years (8.9 years), HbA1c level was 8.2% (2.2%; 66 mmol/mol), eGFR was 86.0 mL/min/1.73 m2 (23.2 mL/min/1.73 m2), and UACR was 155.8 mg/g (542.1 mg/g; median 8.1 mg/g). Those with chronic kidney disease (CKD) (eGFR <60 mL/min/1.73 m2 or UACR >30 mg/g) had smaller GM and higher WML volumes. Higher UACR was significantly associated with higher WML volume and greater atrophy (larger cerebrospinal fluid volumes), and smaller GM and hippocampal WM volumes. A higher eGFR was associated with larger hippocampal WM volumes. Consistent with higher WML volumes, participants with CKD had significantly poorer processing speed and working memory. These findings were independent of glycemic control. We found albuminuria to be a better marker of cerebral structural changes than eGFR in AAs with type 2 diabetes. Relationships between albuminuria and brain pathology may contribute to poorer cognitive performance in patients with mild CKD.
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影响因子：
5.7
作者：
Jovicich J;Czanner S;Han X;Salat D;van der Kouwe A;Quinn B;Pacheco J;Albert M;Killiany R;Blacker D;Maguire P;Rosas D;Makris N;Gollub R;Dale A;Dickerson BC;Fischl B
通讯作者：
Fischl B
影响因子：
4.4
作者：
Knopman, David S.;Mosley, Thomas H., Jr.;Turner, Stephen T.
通讯作者：
Turner, Stephen T.
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
DOI：
10.2215/cjn.05530610
发表时间：
2011-06-01
影响因子：
9.8
作者：
Joosten, Hanneke;Izaks, Gerbrand J.;Gansevoort, Ron T.
通讯作者：
Gansevoort, Ron T.
影响因子：
8.2
作者：
Jongen, C.;van der Grond, J.;Kappelle, L. J.;Biessels, G. J.;Viergever, M. A.;Pluim, J. P. W.
通讯作者：
Pluim, J. P. W.