Covid-19 vaccination and menstrual cycle length in the Apple Women's Health Study.
Covid-19 vaccination and menstrual cycle length in the Apple Women's Health Study.
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DOI：
10.1038/s41746-022-00711-9
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发表时间：
2022-11-02
影响因子：
15.2
通讯作者：
中科院分区：
文献类型：
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作者：
COVID-19疫苗接种可能与疫苗接种后月经周期长度的变化有关。我们估计了符合Apple女性健康研究资格标准的接种疫苗参与者的平均周期长度（MCL）的协变量调整差异（以天为单位测量），Apple女性健康研究是一项基于移动应用程序的纵向队列研究。共有9652例受试者（8486例接种疫苗; 1166例未接种疫苗）贡献了128，094个周期（中位数= 10个周期/受试者;四分位数间距：4-22）。55%的接种疫苗的参与者接受了Pfizer-BioNTech的mRNA疫苗，37%接受了Moderna的mRNA疫苗，8%接受了约翰逊和约翰逊/杨森（J&J）疫苗。与接种前周期相比，COVID-19疫苗接种与参与者接受第一剂（0.50天，95% CI：0.22，0.78）和参与者接受第二剂（0.39天，95% CI：0.11，0.67）mRNA疫苗的周期的MCL小幅增加相关。单次接种强生疫苗的周期平均比接种前周期长1.26天（95% CI：0.45，2.07）。接种后周期恢复到接种前的平均长度。估计卵泡期疫苗接种与参与者接受第一剂疫苗的周期中MCL增加相关（0.97天，95% CI：0.53，1.42）或第二次给药（1.43天，95%CI：1.06，1.80）或强生剂量（2.27天，95%CI：1.04，3.50）。COVID-19疫苗接种后月经周期的变化似乎很小且是暂时的，不应阻止个人接种疫苗。
COVID-19 vaccination may be associated with change in menstrual cycle length following vaccination. We estimated covariate-adjusted differences in mean cycle length (MCL), measured in days, between pre-vaccination cycles, vaccination cycles, and post-vaccination cycles within vaccinated participants who met eligibility criteria in the Apple Women’s Health Study, a longitudinal mobile-application-based cohort of people in the U.S. with manually logged menstrual cycles. A total of 9652 participants (8486 vaccinated; 1166 unvaccinated) contributed 128,094 cycles (median = 10 cycles per participant; inter-quartile range: 4–22). Fifty-five percent of vaccinated participants received Pfizer-BioNTech’s mRNA vaccine, 37% received Moderna’s mRNA vaccine, and 8% received the Johnson & Johnson/Janssen (J&J) vaccine. COVID-19 vaccination was associated with a small increase in MCL for cycles in which participants received the first dose (0.50 days, 95% CI: 0.22, 0.78) and cycles in which participants received the second dose (0.39 days, 95% CI: 0.11, 0.67) of mRNA vaccines compared with pre-vaccination cycles. Cycles in which the single dose of J&J was administered were, on average, 1.26 days longer (95% CI: 0.45, 2.07) than pre-vaccination cycles. Post-vaccination cycles returned to average pre-vaccination length. Estimated follicular phase vaccination was associated with increased MCL in cycles in which participants received the first dose (0.97 days, 95% CI: 0.53, 1.42) or the second dose (1.43 days, 95% CI: 1.06, 1.80) of mRNA vaccines or the J&J dose (2.27 days, 95% CI: 1.04, 3.50), compared with pre-vaccination cycles. Menstrual cycle change following COVID-19 vaccination appears small and temporary and should not discourage individuals from becoming vaccinated.
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DOI：
10.1016/j.bpobgyn.2018.01.007
发表时间：
2018-07-01
影响因子：
5.5
作者：
Jarrell, John
通讯作者：
Jarrell, John
影响因子：
6.1
作者：
Bentov, Y.;Beharier, O.;Klement, A. Hersko
通讯作者：
Klement, A. Hersko
影响因子：
2.7
作者：
Fraser, Ian S.;Critchley, Hilary O. D.;Munro, Malcolm G.
通讯作者：
Munro, Malcolm G.
COVID-19疫苗接种对两个队列中月经期的时间和流动的影响。
影响因子：
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作者：
Alvergne, Alexandra;Woon, Ee Von;Male, Victoria
通讯作者：
Male, Victoria
DOI：
10.1016/j.reprotox.2021.05.007
发表时间：
2021-08
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Bowman CJ;Bouressam M;Campion SN;Cappon GD;Catlin NR;Cutler MW;Diekmann J;Rohde CM;Sellers RS;Lindemann C
通讯作者：
Lindemann C