Alterations of neurometabolism in the dorsolateral prefrontal cortex and thalamus in transition to psychosis patients change under treatment as usual – A two years follow-up 1H/31P-MR-spectroscopy study
Alterations of neurometabolism in the dorsolateral prefrontal cortex and thalamus in transition to psychosis patients change under treatment as usual – A two years follow-up 1H/31P-MR-spectroscopy study
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向精神病患者过渡时，背外侧前额皮质和丘脑的神经代谢变化在照常治疗下发生变化 â 一项为期两年的随访 1H/31P-MR 光谱研究
DOI：
10.1016/j.schres.2020.11.063
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发表时间：
2021
影响因子：
4.5
通讯作者：
Reichenbach JR
中科院分区：
文献类型：
--
作者：
Smesny S;Berberich D;Gussew A;Schönfeld N;Langbein K;Walther M;Reichenbach JR
背景超高风险（UHR）范式允许早期接触患有急性精神病的患者并研究治疗对潜在病理学的影响。方法根据 CAARMS 标准，29 名首次急性精神病患者（过渡患者，TP）（T0）及其 22 名患者在两年随访（平均 788 天）（T1）后接受了前额叶（DLPFC）和前中扣带回的 1H-/31P-MR 波谱分析(aMCC) 皮质和丘脑。通过 ANCOVA 将 N-乙酰天冬氨酸 (NAA)、谷氨酸 (Glu、Glx)、能量 (PCr、ATP) 和磷脂代谢物 (PME、PDE) 与 27 名健康对照进行比较，并与患者的症状评分 (BPRS-E、SCL-90R) 相关。对于纵向分析，使用线性混合模型（LMM）和重复测量的ANCOVA。结果DLPFC：在患者中，在T0时，患者的NAA和PME双侧下降，Glu在左侧下降。随访期间左侧Glu和NAA（趋势）以及双侧Glx增加。丘脑：在TP中，双侧NAA、左侧Glu和右侧Glx在T0时减少；随访期间双侧NAA和左侧Glx增加。aMCC：在TP中，双侧NAA、右侧Glu以及双侧PME和PDE减少，而左侧PCr在T0时增加。随访期间未观察到任何变化。结论无论长期诊断如何，精神病状态都包括 DLPFC、丘脑和 aMCC 神经元功能紊乱。常规治疗 (TAU)，包括抗精神病/抗抑郁药物和支持性心理治疗，对丘脑额叶区有影响，但对 aMCC 的神经代谢缺陷没有影响或不太明显。
BackgroundThe ultra-high risk (UHR) paradigm allows early contact with patients developing acute psychosis and the study of treatment effects on the underlying pathology.Methods29 patients with first acute psychosis according to CAARMS criteria (transition patients, TP) (T0) and thereof 22 patients after two-year follow-up (mean 788 d) (T1) underwent1H-/31P-MR spectroscopy of the prefrontal (DLPFC) and anterior midcingulate (aMCC) cortices and the thalamus.N-acetylaspartate (NAA), glutamate (Glu, Glx), energy (PCr, ATP) and phospholipid metabolites (PME, PDE) were compared to 27 healthy controls by ANCOVA and correlated with patients' symptom ratings (BPRS-E, SCL-90R). For longitudinal analysis, linear mixed model (LMM) and ANCOVA for repeated measures were used.ResultsDLPFC: In patients, NAA and PME were decreased bilaterally and Glu on the left side at T0. Left-sided Glu and NAA (trend) and bilateral Glx increased during follow-up.Thalamus: In TP, bilateral NAA, left-sided Glu and right-sided Glx were decreased at T0; bilateral NAA and left-sided Glx increased during follow-up.aMCC: In TP, bilateral NAA, right-sided Glu, and bilateral PME and PDE were decreased, while left-sided PCr was increased at T0. No changes were observed during follow-up.ConclusionRegardless of the long-term diagnosis, the psychotic state of illness includes disturbed neuronal function in the DLPFC, thalamus and aMCC. Treatment-as-usual (TAU), including antipsychotic/antidepressant medication and supportive psychotherapy, had an effect on the thalamo-frontal area but not or less pronounced on the neurometabolic deficits of the aMCC.
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影响因子：
4.1
作者：
A. Szulc;B. Galińska-Skok;N. Waszkiewicz;D. Bibułowicz;B. Konarzewska;E. Tarasów
通讯作者：
A. Szulc;B. Galińska-Skok;N. Waszkiewicz;D. Bibułowicz;B. Konarzewska;E. Tarasów
首次精神病发作青少年背外侧前额皮质质子磁共振波谱测定结果
DOI：
10.1016/j.pscychresns.2006.12.016
发表时间：
2007
期刊：
Psychiatry Research: Neuroimaging
影响因子：
--
作者：
A. Zabala;J. Sánchez;M. Parellada;D. Moreno;S. Reig;M. Burdalo;O. Robles;M. Desco;C. Arango
通讯作者：
C. Arango
首发精神分裂症脑能量和磷脂代谢的局灶性变化
影响因子：
10.5
作者：
J. Jensen;Jodi E. Miller;P. Williamson;R. Neufeld;Ravi S. Menon;A. Malla;R. Manchanda;B. Schaefer;M. Densmore;D. Drost
通讯作者：
D. Drost
儿科双相情感障碍患者左背外侧前额皮质中 N-乙酰天冬氨酸水平较低。
影响因子：
1.9
作者：
Olvera,ReneL;Caetano,SheilaC;Fonseca,Manoela;Nicoletti,Mark;Stanley,JeffreyA;Chen,HuaHsuan;Hatch,JohnP;Hunter,Kristina;Pliszka,StevenR;Soares,JairC
通讯作者：
Soares,JairC
DOI：
10.1080/j.1440-1614.2005.01714.x
发表时间：
2005-11-01
影响因子：
4.6
作者：
Yung, AR;Yuen, HP;Buckby, J
通讯作者：
Buckby, J